Recombinant multi-species MTHFR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MTHFR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009]
The Alternative Names of target: MTHFR,Methylenetetrahydrofolate reductase (NADPH),Mthfr

Target products collectionGo to MTHFR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP2611-Ag-1/ GM-Tg-hg-IP2611-Ag-2 Human MTHFR protein Human
GM-Tg-rg-IP2611-Ag-1/ GM-Tg-rg-IP2611-Ag-2 Rat MTHFR protein Rat
GM-Tg-mg-IP2611-Ag-1/ GM-Tg-mg-IP2611-Ag-2 Mouse MTHFR protein Mouse
GM-Tg-cynog-IP2611-Ag-1/ GM-Tg-cynog-IP2611-Ag-2 Cynomolgus/Rhesus macaque MTHFR protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP2611-Ag-1/ GM-Tg-felg-IP2611-Ag-2 Feline MTHFR protein Feline
GM-Tg-cang-IP2611-Ag-1/ GM-Tg-cang-IP2611-Ag-2 Canine MTHFR protein Canine
GM-Tg-bovg-IP2611-Ag-1/ GM-Tg-bovg-IP2611-Ag-2 Bovine MTHFR protein Bovine
GM-Tg-equg-IP2611-Ag-1/ GM-Tg-equg-IP2611-Ag-2 Equine MTHFR protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP2611-Ag-1/ GM-Tg-hg-IP2611-Ag-2; GM-Tg-rg-IP2611-Ag-1/ GM-Tg-rg-IP2611-Ag-2;
GM-Tg-mg-IP2611-Ag-1/ GM-Tg-mg-IP2611-Ag-2; GM-Tg-cynog-IP2611-Ag-1/ GM-Tg-cynog-IP2611-Ag-2;
GM-Tg-felg-IP2611-Ag-1/ GM-Tg-felg-IP2611-Ag-2; GM-Tg-cang-IP2611-Ag-1/ GM-Tg-cang-IP2611-Ag-2;
GM-Tg-bovg-IP2611-Ag-1/ GM-Tg-bovg-IP2611-Ag-2; GM-Tg-equg-IP2611-Ag-1/ GM-Tg-equg-IP2611-Ag-2
Products Name MTHFR protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MTHFR
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MTHFR protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.