Recombinant multi-species MAP2K4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MAP2K4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
The Alternative Names of target: Dual specificity mitogen-activated protein kinase kinase 4,JNK-activating kinase 1,JNKK,JNKK1,MAP kinase kinase 4,MAP2K4,MAPK/ERK kinase 4 (MEK 4),MAPKK 4,MAPKK4,MEK4,MKK4,Map2k4,PRKMK4,SAPK/ERK kinase 1 (SEK1),SAPKK-1,SAPKK1,SAPKK1),SEK1,SERK1,SKK1,Sek1,Serk1,Stress-activated protein kinase kinase 1 (SAPK kinase 1,c-Jun N-terminal kinase kinase 1 (JNKK)

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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP2586-Ag-1/ GM-Tg-hg-IP2586-Ag-2 Human MAP2K4 protein Human
GM-Tg-rg-IP2586-Ag-1/ GM-Tg-rg-IP2586-Ag-2 Rat MAP2K4 protein Rat
GM-Tg-mg-IP2586-Ag-1/ GM-Tg-mg-IP2586-Ag-2 Mouse MAP2K4 protein Mouse
GM-Tg-cynog-IP2586-Ag-1/ GM-Tg-cynog-IP2586-Ag-2 Cynomolgus/Rhesus macaque MAP2K4 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP2586-Ag-1/ GM-Tg-felg-IP2586-Ag-2 Feline MAP2K4 protein Feline
GM-Tg-cang-IP2586-Ag-1/ GM-Tg-cang-IP2586-Ag-2 Canine MAP2K4 protein Canine
GM-Tg-bovg-IP2586-Ag-1/ GM-Tg-bovg-IP2586-Ag-2 Bovine MAP2K4 protein Bovine
GM-Tg-equg-IP2586-Ag-1/ GM-Tg-equg-IP2586-Ag-2 Equine MAP2K4 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP2586-Ag-1/ GM-Tg-hg-IP2586-Ag-2; GM-Tg-rg-IP2586-Ag-1/ GM-Tg-rg-IP2586-Ag-2;
GM-Tg-mg-IP2586-Ag-1/ GM-Tg-mg-IP2586-Ag-2; GM-Tg-cynog-IP2586-Ag-1/ GM-Tg-cynog-IP2586-Ag-2;
GM-Tg-felg-IP2586-Ag-1/ GM-Tg-felg-IP2586-Ag-2; GM-Tg-cang-IP2586-Ag-1/ GM-Tg-cang-IP2586-Ag-2;
GM-Tg-bovg-IP2586-Ag-1/ GM-Tg-bovg-IP2586-Ag-2; GM-Tg-equg-IP2586-Ag-1/ GM-Tg-equg-IP2586-Ag-2
Products Name MAP2K4 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MAP2K4
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MAP2K4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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