Explore MAP2K4 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
| Target ID |
GM-IP2586
|
| Target Name |
MAP2K4
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
6416
|
| Gene ID |
100073094 (Equus caballus), 101086432 (Felis catus), 26398 (Mus musculus), 287398 (Rattus norvegicus) 489508 (Canis lupus familiaris), 526469 (Bos taurus), 6416 (Homo sapiens), 718155 (Macaca mulatta)
|
| Target Alternative Names |
Dual specificity mitogen-activated protein kinase kinase 4,JNK-activating kinase 1,JNKK,JNKK1,MAP kinase kinase 4,MAP2K4,MAPK/ERK kinase 4 (MEK 4),MAPKK 4,MAPKK4,MEK4,MKK4,Map2k4,PRKMK4,SAPK/ERK kinase 1 (SEK1),SAPKK-1,SAPKK1,SAPKK1),SEK1,SERK1,SKK1,Sek1,Serk1,Stress-activated protein kinase kinase 1 (SAPK kinase 1,c-Jun N-terminal kinase kinase 1 (JNKK)
|
| Uniprot Accession |
P47809,P45985
|
| Protein Sub-location |
Introcelluar Protein
|
| Disease |
cancer
|
| Disease from KEGG |
MAPK signaling pathway, ErbB signaling pathway, Toll-like receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, GnRH signaling pathway, Relaxin signaling pathway, Growth hormone synthesis, secretion and action, Alcoholic liver disease, Epithelial cell signaling in Helicobacter pylori infection, Yersinia infection, Chagas disease, Hepatitis B, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000025163, ENSMUSG00000033352, ENSCAFG00845003515, ENSBTAG00000012103, ENSG00000065559, ENSMMUG00000019842
|
| Target Classification |
Kinase, Tumor-associated antigen (TAA)
|
Pre-made viral vector of MAP2K4 cDNA Clones/ORF Plasmid
MAP2K4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6416 | Pre-made Human MAP2K4/JNKK/MEK4 siRNA oligo Duplex | 6416 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo287398 | Pre-made Rat Map2k4/MKK4/Sek1 siRNA oligo Duplex | 287398 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo26398 | Pre-made Mouse Map2k4/MEK4/MKK4 siRNA oligo Duplex | 26398 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo718155 | Pre-made Cynomolgus/Rhesus macaque MAP2K4 siRNA oligo Duplex | 718155 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086432 | Pre-made Cat/Feline MAP2K4 siRNA oligo Duplex | 101086432 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489508 | Pre-made Dog/Canine MAP2K4 siRNA oligo Duplex | 489508 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo526469 | Pre-made Bovines/Cattle MAP2K4 siRNA oligo Duplex | 526469 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100073094 | Pre-made Equine/Horse MAP2K4 siRNA oligo Duplex | 100073094 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MAP2K4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP2586-Ab | Human | Anti-Human MAP2K4 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP2586-Ab | Rat | Anti-Rat MAP2K4 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP2586-Ab | Mouse | Anti-Mouse MAP2K4 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP2586-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MAP2K4 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP2586-Ab | Cat/Feline | Anti-Cat/Feline MAP2K4 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP2586-Ab | Dog/Canine | Anti-Dog/Canine MAP2K4 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP2586-Ab | Bovines/Cattle | Anti-Bovines/Cattle MAP2K4 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP2586-Ab | Equine/Horse | Anti-Equine/Horse MAP2K4 monoclonal antibody | mab | | Detail |
MAP2K4 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP2586-Ag | Human | Human MAP2K4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP2586-Ag | Rat | Rat MAP2K4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP2586-Ag | Mouse | Mouse MAP2K4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP2586-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MAP2K4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP2586-Ag | Cat/Feline | Cat/Feline MAP2K4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP2586-Ag | Dog/Canine | Dog/Canine MAP2K4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP2586-Ag | Bovines/Cattle | Bovines/Cattle MAP2K4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP2586-Ag | Equine/Horse | Equine/Horse MAP2K4 recombinant protein | Mammalian cell | Detail |