Recombinant multi-species GLIS2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GLIS2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.[provided by RefSeq, Jan 2010]
The Alternative Names of target: GLI-similar 2,GLIS2,Gli5,Glis2,Klf16,NKL,NPHP7,Neuronal Krueppel-like protein,Nkl,Zinc finger protein GLIS2

Target products collectionGo to GLIS2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP2526-Ag-1/ GM-Tg-hg-IP2526-Ag-2 Human GLIS2 protein Human
GM-Tg-rg-IP2526-Ag-1/ GM-Tg-rg-IP2526-Ag-2 Rat GLIS2 protein Rat
GM-Tg-mg-IP2526-Ag-1/ GM-Tg-mg-IP2526-Ag-2 Mouse GLIS2 protein Mouse
GM-Tg-cynog-IP2526-Ag-1/ GM-Tg-cynog-IP2526-Ag-2 Cynomolgus/Rhesus macaque GLIS2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP2526-Ag-1/ GM-Tg-felg-IP2526-Ag-2 Feline GLIS2 protein Feline
GM-Tg-cang-IP2526-Ag-1/ GM-Tg-cang-IP2526-Ag-2 Canine GLIS2 protein Canine
GM-Tg-bovg-IP2526-Ag-1/ GM-Tg-bovg-IP2526-Ag-2 Bovine GLIS2 protein Bovine
GM-Tg-equg-IP2526-Ag-1/ GM-Tg-equg-IP2526-Ag-2 Equine GLIS2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP2526-Ag-1/ GM-Tg-hg-IP2526-Ag-2; GM-Tg-rg-IP2526-Ag-1/ GM-Tg-rg-IP2526-Ag-2;
GM-Tg-mg-IP2526-Ag-1/ GM-Tg-mg-IP2526-Ag-2; GM-Tg-cynog-IP2526-Ag-1/ GM-Tg-cynog-IP2526-Ag-2;
GM-Tg-felg-IP2526-Ag-1/ GM-Tg-felg-IP2526-Ag-2; GM-Tg-cang-IP2526-Ag-1/ GM-Tg-cang-IP2526-Ag-2;
GM-Tg-bovg-IP2526-Ag-1/ GM-Tg-bovg-IP2526-Ag-2; GM-Tg-equg-IP2526-Ag-1/ GM-Tg-equg-IP2526-Ag-2
Products Name GLIS2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name GLIS2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GLIS2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.