Recombinant multi-species DDB2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DDB2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
The Alternative Names of target: 2610043A19Rik,DDB p48 subunit (DDBb),DDB2,DDBB,DNA damage-binding protein 2,Damage-specific DNA-binding protein 2,Ddb2,UV-DDB2,UV-damaged DNA-binding protein 2 (UV-DDB 2),XPE

Target products collectionGo to DDB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP2450-Ag-1/ GM-Tg-hg-IP2450-Ag-2 Human DDB2 protein Human
GM-Tg-rg-IP2450-Ag-1/ GM-Tg-rg-IP2450-Ag-2 Rat DDB2 protein Rat
GM-Tg-mg-IP2450-Ag-1/ GM-Tg-mg-IP2450-Ag-2 Mouse DDB2 protein Mouse
GM-Tg-cynog-IP2450-Ag-1/ GM-Tg-cynog-IP2450-Ag-2 Cynomolgus/Rhesus macaque DDB2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP2450-Ag-1/ GM-Tg-felg-IP2450-Ag-2 Feline DDB2 protein Feline
GM-Tg-cang-IP2450-Ag-1/ GM-Tg-cang-IP2450-Ag-2 Canine DDB2 protein Canine
GM-Tg-bovg-IP2450-Ag-1/ GM-Tg-bovg-IP2450-Ag-2 Bovine DDB2 protein Bovine
GM-Tg-equg-IP2450-Ag-1/ GM-Tg-equg-IP2450-Ag-2 Equine DDB2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP2450-Ag-1/ GM-Tg-hg-IP2450-Ag-2; GM-Tg-rg-IP2450-Ag-1/ GM-Tg-rg-IP2450-Ag-2;
GM-Tg-mg-IP2450-Ag-1/ GM-Tg-mg-IP2450-Ag-2; GM-Tg-cynog-IP2450-Ag-1/ GM-Tg-cynog-IP2450-Ag-2;
GM-Tg-felg-IP2450-Ag-1/ GM-Tg-felg-IP2450-Ag-2; GM-Tg-cang-IP2450-Ag-1/ GM-Tg-cang-IP2450-Ag-2;
GM-Tg-bovg-IP2450-Ag-1/ GM-Tg-bovg-IP2450-Ag-2; GM-Tg-equg-IP2450-Ag-1/ GM-Tg-equg-IP2450-Ag-2
Products Name DDB2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name DDB2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DDB2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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