Recombinant multi-species CHD8 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CHD8 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which are common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. This gene has been shown to function in several processes that include transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Allelic variants of this gene are associated with autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]
The Alternative Names of target: 5830451P18Rik,ATP-dependent helicase CHD8,AUTS18,CHD-8,CHD8,Chd-8,Chd8,Chromodomain-helicase-DNA-binding protein 8,Duplin,HELSNF1,Helicase with SNF2 domain 1,IDDAM,mKIAA1564

Target products collectionGo to CHD8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP2428-Ag-1/ GM-Tg-hg-IP2428-Ag-2 Human CHD8 protein Human
GM-Tg-rg-IP2428-Ag-1/ GM-Tg-rg-IP2428-Ag-2 Rat CHD8 protein Rat
GM-Tg-mg-IP2428-Ag-1/ GM-Tg-mg-IP2428-Ag-2 Mouse CHD8 protein Mouse
GM-Tg-cynog-IP2428-Ag-1/ GM-Tg-cynog-IP2428-Ag-2 Cynomolgus/Rhesus macaque CHD8 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP2428-Ag-1/ GM-Tg-felg-IP2428-Ag-2 Feline CHD8 protein Feline
GM-Tg-cang-IP2428-Ag-1/ GM-Tg-cang-IP2428-Ag-2 Canine CHD8 protein Canine
GM-Tg-bovg-IP2428-Ag-1/ GM-Tg-bovg-IP2428-Ag-2 Bovine CHD8 protein Bovine
GM-Tg-equg-IP2428-Ag-1/ GM-Tg-equg-IP2428-Ag-2 Equine CHD8 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP2428-Ag-1/ GM-Tg-hg-IP2428-Ag-2; GM-Tg-rg-IP2428-Ag-1/ GM-Tg-rg-IP2428-Ag-2;
GM-Tg-mg-IP2428-Ag-1/ GM-Tg-mg-IP2428-Ag-2; GM-Tg-cynog-IP2428-Ag-1/ GM-Tg-cynog-IP2428-Ag-2;
GM-Tg-felg-IP2428-Ag-1/ GM-Tg-felg-IP2428-Ag-2; GM-Tg-cang-IP2428-Ag-1/ GM-Tg-cang-IP2428-Ag-2;
GM-Tg-bovg-IP2428-Ag-1/ GM-Tg-bovg-IP2428-Ag-2; GM-Tg-equg-IP2428-Ag-1/ GM-Tg-equg-IP2428-Ag-2
Products Name CHD8 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CHD8
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CHD8 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.