Recombinant multi-species Tuberin/TSC2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Tuberin/TSC2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is a tumor suppressor gene that encodes the growth inhibitory protein tuberin. Tuberin interacts with hamartin to form the TSC protein complex which functions in the control of cell growth. This TSC protein complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis. [provided by RefSeq, May 2022]
The Alternative Names of target: LAM,Nafld,PPP1R160,Rc,TSC2,TSC4,Tcs2,Tsc2,Tuberin,Tuberous sclerosis 2 protein

Target products collectionGo to Tuberin/TSC2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP2180-Ag-1/ GM-Tg-hg-IP2180-Ag-2 Human Tuberin/TSC2 protein Human
GM-Tg-rg-IP2180-Ag-1/ GM-Tg-rg-IP2180-Ag-2 Rat Tuberin/TSC2 protein Rat
GM-Tg-mg-IP2180-Ag-1/ GM-Tg-mg-IP2180-Ag-2 Mouse Tuberin/TSC2 protein Mouse
GM-Tg-cynog-IP2180-Ag-1/ GM-Tg-cynog-IP2180-Ag-2 Cynomolgus/Rhesus macaque Tuberin/TSC2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP2180-Ag-1/ GM-Tg-felg-IP2180-Ag-2 Feline Tuberin/TSC2 protein Feline
GM-Tg-cang-IP2180-Ag-1/ GM-Tg-cang-IP2180-Ag-2 Canine Tuberin/TSC2 protein Canine
GM-Tg-bovg-IP2180-Ag-1/ GM-Tg-bovg-IP2180-Ag-2 Bovine Tuberin/TSC2 protein Bovine
GM-Tg-equg-IP2180-Ag-1/ GM-Tg-equg-IP2180-Ag-2 Equine Tuberin/TSC2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP2180-Ag-1/ GM-Tg-hg-IP2180-Ag-2; GM-Tg-rg-IP2180-Ag-1/ GM-Tg-rg-IP2180-Ag-2;
GM-Tg-mg-IP2180-Ag-1/ GM-Tg-mg-IP2180-Ag-2; GM-Tg-cynog-IP2180-Ag-1/ GM-Tg-cynog-IP2180-Ag-2;
GM-Tg-felg-IP2180-Ag-1/ GM-Tg-felg-IP2180-Ag-2; GM-Tg-cang-IP2180-Ag-1/ GM-Tg-cang-IP2180-Ag-2;
GM-Tg-bovg-IP2180-Ag-1/ GM-Tg-bovg-IP2180-Ag-2; GM-Tg-equg-IP2180-Ag-1/ GM-Tg-equg-IP2180-Ag-2
Products Name Tuberin/TSC2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Tuberin/TSC2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Tuberin/TSC2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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