Explore Tuberin/TSC2 gene products and cross-species
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biological information, expression tools, and therapeutic
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Target
sublocation: Introcelluar Protein.
This gene is a tumor suppressor gene that encodes the growth inhibitory protein tuberin. Tuberin interacts with hamartin to form the TSC protein complex which functions in the control of cell growth. This TSC protein complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis. [provided by RefSeq, May 2022]
| Target ID |
GM-IP2180
|
| Target Name |
Tuberin/TSC2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
7249
|
| Gene ID |
100065679 (Equus caballus), 101082969 (Felis catus), 22084 (Mus musculus), 24855 (Rattus norvegicus)
479883 (Canis lupus familiaris), 504985 (Bos taurus), 694965 (Macaca mulatta), 7249 (Homo sapiens)
|
| Target Alternative Names |
LAM,Nafld,PPP1R160,Rc,TSC2,TSC4,Tcs2,Tsc2,Tuberin,Tuberous sclerosis 2 protein
|
| Uniprot Accession |
Q61037,P49816,P49815
|
| Protein Sub-location |
Introcelluar Protein
|
| Disease |
cancer
|
| Disease from KEGG |
Phospholipase D signaling pathway, p53 signaling pathway, PI3K-Akt signaling pathway, Longevity regulating pathway, Cellular senescence, Thyroid hormone signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, Choline metabolism in cancer
|
| Gene Ensembl |
ENSECAG00000021222, ENSMUSG00000002496, ENSCAFG00845016084, ENSBTAG00000020617, ENSMMUG00000002808, ENSG00000103197
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of Tuberin/TSC2 cDNA Clones/ORF Plasmid
Tuberin/TSC2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7249 | Pre-made Human TSC2/LAM/TSC4 siRNA oligo Duplex | 7249 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24855 | Pre-made Rat Tsc2/Rc siRNA oligo Duplex | 24855 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22084 | Pre-made Mouse Tsc2/Tcs2/Nafld siRNA oligo Duplex | 22084 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo694965 | Pre-made Cynomolgus/Rhesus macaque TSC2 siRNA oligo Duplex | 694965 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082969 | Pre-made Cat/Feline TSC2 siRNA oligo Duplex | 101082969 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo479883 | Pre-made Dog/Canine TSC2 siRNA oligo Duplex | 479883 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo504985 | Pre-made Bovines/Cattle TSC2 siRNA oligo Duplex | 504985 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100065679 | Pre-made Equine/Horse TSC2 siRNA oligo Duplex | 100065679 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Tuberin/TSC2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP2180-Ab | Human | Anti-Human Tuberin/TSC2 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP2180-Ab | Rat | Anti-Rat Tuberin/TSC2 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP2180-Ab | Mouse | Anti-Mouse Tuberin/TSC2 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP2180-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Tuberin/TSC2 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP2180-Ab | Cat/Feline | Anti-Cat/Feline Tuberin/TSC2 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP2180-Ab | Dog/Canine | Anti-Dog/Canine Tuberin/TSC2 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP2180-Ab | Bovines/Cattle | Anti-Bovines/Cattle Tuberin/TSC2 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP2180-Ab | Equine/Horse | Anti-Equine/Horse Tuberin/TSC2 monoclonal antibody | mab | | Detail |
Tuberin/TSC2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP2180-Ag | Human | Human Tuberin/TSC2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP2180-Ag | Rat | Rat Tuberin/TSC2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP2180-Ag | Mouse | Mouse Tuberin/TSC2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP2180-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Tuberin/TSC2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP2180-Ag | Cat/Feline | Cat/Feline Tuberin/TSC2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP2180-Ag | Dog/Canine | Dog/Canine Tuberin/TSC2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP2180-Ag | Bovines/Cattle | Bovines/Cattle Tuberin/TSC2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP2180-Ag | Equine/Horse | Equine/Horse Tuberin/TSC2 recombinant protein | Mammalian cell | Detail |
