Recombinant multi-species MED12 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MED12 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]
The Alternative Names of target: 230kDa,ARC240,Activator-recruited cofactor 240 kDa component (ARC240),CAG repeat protein 45,CAGH45,FGS1,HDKR,HOPA,Kto,MED12,MED12S,Med12,Mediator complex subunit 12,Mediator of RNA polymerase II transcription subunit 12,Mopa,OHDOX,OKS,OPA-1,OPA-containing protein,OPA1,TNRC11,TRAP230,Thyroid hormone receptor-associated protein complex 230 kDa component (Trap230),Tnrc11,Trap230,Trinucleotide repeat-containing gene 11 protein

Target products collectionGo to MED12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP14017-Ag-1/ GM-Tg-hg-IP14017-Ag-2 Human MED12 protein Human
GM-Tg-rg-IP14017-Ag-1/ GM-Tg-rg-IP14017-Ag-2 Rat MED12 protein Rat
GM-Tg-mg-IP14017-Ag-1/ GM-Tg-mg-IP14017-Ag-2 Mouse MED12 protein Mouse
GM-Tg-cynog-IP14017-Ag-1/ GM-Tg-cynog-IP14017-Ag-2 Cynomolgus/Rhesus macaque MED12 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP14017-Ag-1/ GM-Tg-felg-IP14017-Ag-2 Feline MED12 protein Feline
GM-Tg-cang-IP14017-Ag-1/ GM-Tg-cang-IP14017-Ag-2 Canine MED12 protein Canine
GM-Tg-bovg-IP14017-Ag-1/ GM-Tg-bovg-IP14017-Ag-2 Bovine MED12 protein Bovine
GM-Tg-equg-IP14017-Ag-1/ GM-Tg-equg-IP14017-Ag-2 Equine MED12 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP14017-Ag-1/ GM-Tg-hg-IP14017-Ag-2; GM-Tg-rg-IP14017-Ag-1/ GM-Tg-rg-IP14017-Ag-2;
GM-Tg-mg-IP14017-Ag-1/ GM-Tg-mg-IP14017-Ag-2; GM-Tg-cynog-IP14017-Ag-1/ GM-Tg-cynog-IP14017-Ag-2;
GM-Tg-felg-IP14017-Ag-1/ GM-Tg-felg-IP14017-Ag-2; GM-Tg-cang-IP14017-Ag-1/ GM-Tg-cang-IP14017-Ag-2;
GM-Tg-bovg-IP14017-Ag-1/ GM-Tg-bovg-IP14017-Ag-2; GM-Tg-equg-IP14017-Ag-1/ GM-Tg-equg-IP14017-Ag-2
Products Name MED12 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MED12
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MED12 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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