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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]
| Target ID |
GM-IP14017
|
| Target Name |
MED12
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
9968
|
| Gene ID |
100056909 (Equus caballus), 100855688 (Canis lupus familiaris), 101090673 (Felis catus), 520974 (Bos taurus)
59024 (Mus musculus), 679693 (Rattus norvegicus), 696791 (Macaca mulatta), 9968 (Homo sapiens)
|
| Target Alternative Names |
230kDa,ARC240,Activator-recruited cofactor 240 kDa component (ARC240),CAG repeat protein 45,CAGH45,FGS1,HDKR,HOPA,Kto,MED12,MED12S,Med12,Mediator complex subunit 12,Mediator of RNA polymerase II transcription subunit 12,Mopa,OHDOX,OKS,OPA-1,OPA-containing protein,OPA1,TNRC11,TRAP230,Thyroid hormone receptor-associated protein complex 230 kDa component (Trap230),Tnrc11,Trap230,Trinucleotide repeat-containing gene 11 protein
|
| Uniprot Accession |
A2AGH6,Q93074
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000023931, ENSBTAG00000021351, ENSMUSG00000079487, ENSMMUG00000017797, ENSG00000184634
|
MED12 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo9968 | Pre-made Human MED12/Kto/OKS siRNA oligo Duplex | 9968 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo679693 | Pre-made Rat Med12 siRNA oligo Duplex | 679693 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo59024 | Pre-made Mouse Med12/Mopa/OPA-1 siRNA oligo Duplex | 59024 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo696791 | Pre-made Cynomolgus/Rhesus macaque MED12 siRNA oligo Duplex | 696791 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090673 | Pre-made Cat/Feline MED12 siRNA oligo Duplex | 101090673 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100855688 | Pre-made Dog/Canine MED12 siRNA oligo Duplex | 100855688 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo520974 | Pre-made Bovines/Cattle MED12 siRNA oligo Duplex | 520974 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100056909 | Pre-made Equine/Horse MED12 siRNA oligo Duplex | 100056909 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MED12 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP14017-Ab | Human | Anti-Human MED12 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP14017-Ab | Rat | Anti-Rat MED12 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP14017-Ab | Mouse | Anti-Mouse MED12 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP14017-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MED12 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP14017-Ab | Cat/Feline | Anti-Cat/Feline MED12 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP14017-Ab | Dog/Canine | Anti-Dog/Canine MED12 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP14017-Ab | Bovines/Cattle | Anti-Bovines/Cattle MED12 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP14017-Ab | Equine/Horse | Anti-Equine/Horse MED12 monoclonal antibody | mab | | Detail |
MED12 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP14017-Ag | Human | Human MED12 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP14017-Ag | Rat | Rat MED12 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP14017-Ag | Mouse | Mouse MED12 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP14017-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MED12 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP14017-Ag | Cat/Feline | Cat/Feline MED12 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP14017-Ag | Dog/Canine | Dog/Canine MED12 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP14017-Ag | Bovines/Cattle | Bovines/Cattle MED12 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP14017-Ag | Equine/Horse | Equine/Horse MED12 recombinant protein | Mammalian cell | Detail |
