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Recombinant multi-species Cyclin T1/CCNT1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Cyclin T1/CCNT1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
The Alternative Names of target: 2810478G24Rik,CCNT,CCNT1,CYCT1,Ccnt1,CycT1,Cyclin T1,Cyclin-T,Cyclin-T1,HIVE1
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MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP13415-Ag-1/ GM-Tg-hg-IP13415-Ag-2 | Human Cyclin T1/CCNT1 protein | Human |
| GM-Tg-rg-IP13415-Ag-1/ GM-Tg-rg-IP13415-Ag-2 | Rat Cyclin T1/CCNT1 protein | Rat |
| GM-Tg-mg-IP13415-Ag-1/ GM-Tg-mg-IP13415-Ag-2 | Mouse Cyclin T1/CCNT1 protein | Mouse |
| GM-Tg-cynog-IP13415-Ag-1/ GM-Tg-cynog-IP13415-Ag-2 | Cynomolgus/Rhesus macaque Cyclin T1/CCNT1 protein | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP13415-Ag-1/ GM-Tg-felg-IP13415-Ag-2 | Feline Cyclin T1/CCNT1 protein | Feline |
| GM-Tg-cang-IP13415-Ag-1/ GM-Tg-cang-IP13415-Ag-2 | Canine Cyclin T1/CCNT1 protein | Canine |
| GM-Tg-bovg-IP13415-Ag-1/ GM-Tg-bovg-IP13415-Ag-2 | Bovine Cyclin T1/CCNT1 protein | Bovine |
| GM-Tg-equg-IP13415-Ag-1/ GM-Tg-equg-IP13415-Ag-2 | Equine Cyclin T1/CCNT1 protein | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-IP13415-Ag-1/ GM-Tg-hg-IP13415-Ag-2;
GM-Tg-rg-IP13415-Ag-1/ GM-Tg-rg-IP13415-Ag-2;
GM-Tg-mg-IP13415-Ag-1/ GM-Tg-mg-IP13415-Ag-2; GM-Tg-cynog-IP13415-Ag-1/ GM-Tg-cynog-IP13415-Ag-2; GM-Tg-felg-IP13415-Ag-1/ GM-Tg-felg-IP13415-Ag-2; GM-Tg-cang-IP13415-Ag-1/ GM-Tg-cang-IP13415-Ag-2; GM-Tg-bovg-IP13415-Ag-1/ GM-Tg-bovg-IP13415-Ag-2; GM-Tg-equg-IP13415-Ag-1/ GM-Tg-equg-IP13415-Ag-2 |
| Products Name | Cyclin T1/CCNT1 protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | Cyclin T1/CCNT1 |
| Protein Sub-location | Introcelluar Protein |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Cyclin T1/CCNT1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
About Gmab
GMab, developed by GeneMedi, constitutes an
advanced library of recombinant
monoclonal antibodies, each meticulously
designed to target specific molecular
entities. Leveraging the sophisticated
capabilities of GM’s Taurus™ and LIBRA™
platforms, GMab synthesizes antibodies
characterized by high binding affinity,
exceptional physicochemical stability, and
optimal developability profiles.
Through
expression in mammalian cell lines, GMab has
been established as a paradigmatic
reference antibody. It holds significance in
myriad domains of biological drug
discovery, encompassing cellular cultivation,
innovative assay methodologies,
strategic animal model systematization, in-depth
pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.