Recombinant multi-species FADD protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FADD protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
The Alternative Names of target: FADD,FAS-associated death domain protein,FAS-associating death domain-containing protein,Fadd,GIG3,Growth-inhibiting gene 3 protein,IMD90,MORT1,Mediator of receptor induced toxicity,Mort1,Mort1/FADD

Target products collectionGo to FADD products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP13272-Ag-1/ GM-Tg-hg-IP13272-Ag-2 Human FADD protein Human
GM-Tg-rg-IP13272-Ag-1/ GM-Tg-rg-IP13272-Ag-2 Rat FADD protein Rat
GM-Tg-mg-IP13272-Ag-1/ GM-Tg-mg-IP13272-Ag-2 Mouse FADD protein Mouse
GM-Tg-cynog-IP13272-Ag-1/ GM-Tg-cynog-IP13272-Ag-2 Cynomolgus/Rhesus macaque FADD protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP13272-Ag-1/ GM-Tg-felg-IP13272-Ag-2 Feline FADD protein Feline
GM-Tg-cang-IP13272-Ag-1/ GM-Tg-cang-IP13272-Ag-2 Canine FADD protein Canine
GM-Tg-bovg-IP13272-Ag-1/ GM-Tg-bovg-IP13272-Ag-2 Bovine FADD protein Bovine
GM-Tg-equg-IP13272-Ag-1/ GM-Tg-equg-IP13272-Ag-2 Equine FADD protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP13272-Ag-1/ GM-Tg-hg-IP13272-Ag-2; GM-Tg-rg-IP13272-Ag-1/ GM-Tg-rg-IP13272-Ag-2;
GM-Tg-mg-IP13272-Ag-1/ GM-Tg-mg-IP13272-Ag-2; GM-Tg-cynog-IP13272-Ag-1/ GM-Tg-cynog-IP13272-Ag-2;
GM-Tg-felg-IP13272-Ag-1/ GM-Tg-felg-IP13272-Ag-2; GM-Tg-cang-IP13272-Ag-1/ GM-Tg-cang-IP13272-Ag-2;
GM-Tg-bovg-IP13272-Ag-1/ GM-Tg-bovg-IP13272-Ag-2; GM-Tg-equg-IP13272-Ag-1/ GM-Tg-equg-IP13272-Ag-2
Products Name FADD protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name FADD
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FADD protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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