Recombinant multi-species AXIN1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine AXIN1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
The Alternative Names of target: AXIN,AXIN1,Axin,Axin-1,Axin1,Axis inhibition protein 1 (hAxin),CMDOH,Fu,Kb,Ki,PPP1R49,axin-1,fused,kinky,knobbly

Target products collectionGo to AXIN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP12632-Ag-1/ GM-Tg-hg-IP12632-Ag-2 Human AXIN1 protein Human
GM-Tg-rg-IP12632-Ag-1/ GM-Tg-rg-IP12632-Ag-2 Rat AXIN1 protein Rat
GM-Tg-mg-IP12632-Ag-1/ GM-Tg-mg-IP12632-Ag-2 Mouse AXIN1 protein Mouse
GM-Tg-cynog-IP12632-Ag-1/ GM-Tg-cynog-IP12632-Ag-2 Cynomolgus/Rhesus macaque AXIN1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP12632-Ag-1/ GM-Tg-felg-IP12632-Ag-2 Feline AXIN1 protein Feline
GM-Tg-cang-IP12632-Ag-1/ GM-Tg-cang-IP12632-Ag-2 Canine AXIN1 protein Canine
GM-Tg-bovg-IP12632-Ag-1/ GM-Tg-bovg-IP12632-Ag-2 Bovine AXIN1 protein Bovine
GM-Tg-equg-IP12632-Ag-1/ GM-Tg-equg-IP12632-Ag-2 Equine AXIN1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP12632-Ag-1/ GM-Tg-hg-IP12632-Ag-2; GM-Tg-rg-IP12632-Ag-1/ GM-Tg-rg-IP12632-Ag-2;
GM-Tg-mg-IP12632-Ag-1/ GM-Tg-mg-IP12632-Ag-2; GM-Tg-cynog-IP12632-Ag-1/ GM-Tg-cynog-IP12632-Ag-2;
GM-Tg-felg-IP12632-Ag-1/ GM-Tg-felg-IP12632-Ag-2; GM-Tg-cang-IP12632-Ag-1/ GM-Tg-cang-IP12632-Ag-2;
GM-Tg-bovg-IP12632-Ag-1/ GM-Tg-bovg-IP12632-Ag-2; GM-Tg-equg-IP12632-Ag-1/ GM-Tg-equg-IP12632-Ag-2
Products Name AXIN1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name AXIN1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine AXIN1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.