Explore AXIN1 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
| Target ID |
GM-IP12632
|
| Target Name |
AXIN1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
8312
|
| Gene ID |
100065116 (Equus caballus), 100424087 (Macaca mulatta), 101088804 (Felis catus), 12005 (Mus musculus) 490099 (Canis lupus familiaris), 504357 (Bos taurus), 79257 (Rattus norvegicus), 8312 (Homo sapiens)
|
| Target Alternative Names |
AXIN,AXIN1,Axin,Axin-1,Axin1,Axis inhibition protein 1 (hAxin),CMDOH,Fu,Kb,Ki,PPP1R49,axin-1,fused,kinky,knobbly
|
| Uniprot Accession |
O35625,O70239,O15169
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000023674, ENSMMUG00000000605, ENSMUSG00000024182, ENSCAFG00845028817, ENSBTAG00000016577, ENSG00000103126
|
Pre-made viral vector of AXIN1 cDNA Clones/ORF Plasmid
AXIN1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8312 | Pre-made Human AXIN1/AXIN/CMDOH siRNA oligo Duplex | 8312 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo79257 | Pre-made Rat Axin1/Axin/axin-1 siRNA oligo Duplex | 79257 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12005 | Pre-made Mouse Axin1/Fu/Kb siRNA oligo Duplex | 12005 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100424087 | Pre-made Cynomolgus/Rhesus macaque AXIN1 siRNA oligo Duplex | 100424087 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101088804 | Pre-made Cat/Feline AXIN1 siRNA oligo Duplex | 101088804 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo490099 | Pre-made Dog/Canine AXIN1 siRNA oligo Duplex | 490099 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo504357 | Pre-made Bovines/Cattle AXIN1 siRNA oligo Duplex | 504357 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100065116 | Pre-made Equine/Horse AXIN1 siRNA oligo Duplex | 100065116 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
AXIN1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP12632-Ab | Human | Anti-Human AXIN1 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP12632-Ab | Rat | Anti-Rat AXIN1 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP12632-Ab | Mouse | Anti-Mouse AXIN1 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP12632-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque AXIN1 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP12632-Ab | Cat/Feline | Anti-Cat/Feline AXIN1 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP12632-Ab | Dog/Canine | Anti-Dog/Canine AXIN1 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP12632-Ab | Bovines/Cattle | Anti-Bovines/Cattle AXIN1 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP12632-Ab | Equine/Horse | Anti-Equine/Horse AXIN1 monoclonal antibody | mab | | Detail |
AXIN1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP12632-Ag | Human | Human AXIN1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP12632-Ag | Rat | Rat AXIN1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP12632-Ag | Mouse | Mouse AXIN1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP12632-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque AXIN1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP12632-Ag | Cat/Feline | Cat/Feline AXIN1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP12632-Ag | Dog/Canine | Dog/Canine AXIN1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP12632-Ag | Bovines/Cattle | Bovines/Cattle AXIN1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP12632-Ag | Equine/Horse | Equine/Horse AXIN1 recombinant protein | Mammalian cell | Detail |