Recombinant multi-species BLM protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BLM protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The Bloom syndrome is an autosomal recessive disorder characterized by growth deficiency, microcephaly and immunodeficiency among others. It is caused by homozygous or compound heterozygous mutation in the gene encoding DNA helicase RecQ protein on chromosome 15q26. This Bloom-associated helicase unwinds a variety of DNA substrates including Holliday junction, and is involved in several pathways contributing to the maintenance of genome stability. Identification of pathogenic Bloom variants is required for heterozygote testing in at-risk families. [provided by RefSeq, May 2020]
The Alternative Names of target: BLM,BS,Blm,Bloom syndrome protein,DNA 3'-5' helicase BLM,DNA helicase,MGRISCE1,RECQ2,RECQL2,RECQL3,RecQ protein-like 3,RecQ-like DNA helicase BLM,RecQ-like type 2 (RecQ2)

Target products collectionGo to BLM products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP11106-Ag-1/ GM-Tg-hg-IP11106-Ag-2 Human BLM protein Human
GM-Tg-rg-IP11106-Ag-1/ GM-Tg-rg-IP11106-Ag-2 Rat BLM protein Rat
GM-Tg-mg-IP11106-Ag-1/ GM-Tg-mg-IP11106-Ag-2 Mouse BLM protein Mouse
GM-Tg-cynog-IP11106-Ag-1/ GM-Tg-cynog-IP11106-Ag-2 Cynomolgus/Rhesus macaque BLM protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP11106-Ag-1/ GM-Tg-felg-IP11106-Ag-2 Feline BLM protein Feline
GM-Tg-cang-IP11106-Ag-1/ GM-Tg-cang-IP11106-Ag-2 Canine BLM protein Canine
GM-Tg-bovg-IP11106-Ag-1/ GM-Tg-bovg-IP11106-Ag-2 Bovine BLM protein Bovine
GM-Tg-equg-IP11106-Ag-1/ GM-Tg-equg-IP11106-Ag-2 Equine BLM protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP11106-Ag-1/ GM-Tg-hg-IP11106-Ag-2; GM-Tg-rg-IP11106-Ag-1/ GM-Tg-rg-IP11106-Ag-2;
GM-Tg-mg-IP11106-Ag-1/ GM-Tg-mg-IP11106-Ag-2; GM-Tg-cynog-IP11106-Ag-1/ GM-Tg-cynog-IP11106-Ag-2;
GM-Tg-felg-IP11106-Ag-1/ GM-Tg-felg-IP11106-Ag-2; GM-Tg-cang-IP11106-Ag-1/ GM-Tg-cang-IP11106-Ag-2;
GM-Tg-bovg-IP11106-Ag-1/ GM-Tg-bovg-IP11106-Ag-2; GM-Tg-equg-IP11106-Ag-1/ GM-Tg-equg-IP11106-Ag-2
Products Name BLM protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name BLM
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BLM protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.