Recombinant multi-species UPF1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine UPF1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
The Alternative Names of target: ATP-dependent helicase RENT1,B430202H16Rik,HUPF1,NORF1,Nonsense mRNA reducing factor 1 (NORF1),PNORF-1,RENT1,Regulator of nonsense transcripts 1,Rent1,UPF1,UTF,Up-frameshift suppressor 1 homolog (hUpf1),Upf1,Upflp,pNORF1,smg-2

Target products collectionGo to UPF1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP10887-Ag-1/ GM-Tg-hg-IP10887-Ag-2 Human UPF1 protein Human
GM-Tg-rg-IP10887-Ag-1/ GM-Tg-rg-IP10887-Ag-2 Rat UPF1 protein Rat
GM-Tg-mg-IP10887-Ag-1/ GM-Tg-mg-IP10887-Ag-2 Mouse UPF1 protein Mouse
GM-Tg-cynog-IP10887-Ag-1/ GM-Tg-cynog-IP10887-Ag-2 Cynomolgus/Rhesus macaque UPF1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP10887-Ag-1/ GM-Tg-felg-IP10887-Ag-2 Feline UPF1 protein Feline
GM-Tg-cang-IP10887-Ag-1/ GM-Tg-cang-IP10887-Ag-2 Canine UPF1 protein Canine
GM-Tg-bovg-IP10887-Ag-1/ GM-Tg-bovg-IP10887-Ag-2 Bovine UPF1 protein Bovine
GM-Tg-equg-IP10887-Ag-1/ GM-Tg-equg-IP10887-Ag-2 Equine UPF1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP10887-Ag-1/ GM-Tg-hg-IP10887-Ag-2; GM-Tg-rg-IP10887-Ag-1/ GM-Tg-rg-IP10887-Ag-2;
GM-Tg-mg-IP10887-Ag-1/ GM-Tg-mg-IP10887-Ag-2; GM-Tg-cynog-IP10887-Ag-1/ GM-Tg-cynog-IP10887-Ag-2;
GM-Tg-felg-IP10887-Ag-1/ GM-Tg-felg-IP10887-Ag-2; GM-Tg-cang-IP10887-Ag-1/ GM-Tg-cang-IP10887-Ag-2;
GM-Tg-bovg-IP10887-Ag-1/ GM-Tg-bovg-IP10887-Ag-2; GM-Tg-equg-IP10887-Ag-1/ GM-Tg-equg-IP10887-Ag-2
Products Name UPF1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name UPF1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine UPF1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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