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Target
sublocation: Introcelluar Protein.
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
| Target ID |
GM-IP10887
|
| Target Name |
UPF1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5976
|
| Gene ID |
100071059 (Equus caballus), 101096043 (Felis catus), 19704 (Mus musculus), 476664 (Canis lupus familiaris)
532933 (Bos taurus), 5976 (Homo sapiens), 684558 (Rattus norvegicus), 720288 (Macaca mulatta)
|
| Target Alternative Names |
ATP-dependent helicase RENT1,B430202H16Rik,HUPF1,NORF1,Nonsense mRNA reducing factor 1 (NORF1),PNORF-1,RENT1,Regulator of nonsense transcripts 1,Rent1,UPF1,UTF,Up-frameshift suppressor 1 homolog (hUpf1),Upf1,Upflp,pNORF1,smg-2
|
| Uniprot Accession |
Q9EPU0,Q92900
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Gene Ensembl |
ENSECAG00000010639, ENSMUSG00000058301, ENSCAFG00845019866, ENSBTAG00000020922, ENSG00000005007, ENSMMUG00000023286
|
UPF1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5976 | Pre-made Human UPF1/UTF/HUPF1 siRNA oligo Duplex | 5976 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo684558 | Pre-made Rat Upf1 siRNA oligo Duplex | 684558 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19704 | Pre-made Mouse Upf1/NORF1/Rent1 siRNA oligo Duplex | 19704 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo720288 | Pre-made Cynomolgus/Rhesus macaque UPF1 siRNA oligo Duplex | 720288 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096043 | Pre-made Cat/Feline UPF1 siRNA oligo Duplex | 101096043 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo476664 | Pre-made Dog/Canine UPF1 siRNA oligo Duplex | 476664 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo532933 | Pre-made Bovines/Cattle UPF1 siRNA oligo Duplex | 532933 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100071059 | Pre-made Equine/Horse UPF1 siRNA oligo Duplex | 100071059 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
UPF1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP10887-Ab | Human | Anti-Human UPF1 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP10887-Ab | Rat | Anti-Rat UPF1 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP10887-Ab | Mouse | Anti-Mouse UPF1 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP10887-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque UPF1 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP10887-Ab | Cat/Feline | Anti-Cat/Feline UPF1 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP10887-Ab | Dog/Canine | Anti-Dog/Canine UPF1 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP10887-Ab | Bovines/Cattle | Anti-Bovines/Cattle UPF1 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP10887-Ab | Equine/Horse | Anti-Equine/Horse UPF1 monoclonal antibody | mab | | Detail |
UPF1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP10887-Ag | Human | Human UPF1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP10887-Ag | Rat | Rat UPF1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP10887-Ag | Mouse | Mouse UPF1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP10887-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque UPF1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP10887-Ag | Cat/Feline | Cat/Feline UPF1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP10887-Ag | Dog/Canine | Dog/Canine UPF1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP10887-Ag | Bovines/Cattle | Bovines/Cattle UPF1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP10887-Ag | Equine/Horse | Equine/Horse UPF1 recombinant protein | Mammalian cell | Detail |
