Recombinant multi-species Twinkle/PEO1/TWNK protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Twinkle/PEO1/TWNK protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Aug 2009]
The Alternative Names of target: ATXN8,C10orf2,C1H10orf2,C26H10orf2,C28H10orf2,C9H10orf2,CD2H10orf2,D19Ertd626e,IOSCA,MTDPS7,PEO,PEO1,PEOA3,PRLTS5,Peo1,Progressive external ophthalmoplegia 1 protein,SANDO,SCA8,T7 gp4-like protein with intramitochondrial nucleoid localization,T7-like mitochondrial DNA helicase,TWINL,TWNK,Twinkle,Twinkle mtDNA helicase,Twinkle protein,Twinl,Twnk,mitochondrial,twinkle

Target products collectionGo to Twinkle/PEO1/TWNK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP10422-Ag-1/ GM-Tg-hg-IP10422-Ag-2 Human Twinkle/PEO1/TWNK protein Human
GM-Tg-rg-IP10422-Ag-1/ GM-Tg-rg-IP10422-Ag-2 Rat Twinkle/PEO1/TWNK protein Rat
GM-Tg-mg-IP10422-Ag-1/ GM-Tg-mg-IP10422-Ag-2 Mouse Twinkle/PEO1/TWNK protein Mouse
GM-Tg-cynog-IP10422-Ag-1/ GM-Tg-cynog-IP10422-Ag-2 Cynomolgus/Rhesus macaque Twinkle/PEO1/TWNK protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP10422-Ag-1/ GM-Tg-felg-IP10422-Ag-2 Feline Twinkle/PEO1/TWNK protein Feline
GM-Tg-cang-IP10422-Ag-1/ GM-Tg-cang-IP10422-Ag-2 Canine Twinkle/PEO1/TWNK protein Canine
GM-Tg-bovg-IP10422-Ag-1/ GM-Tg-bovg-IP10422-Ag-2 Bovine Twinkle/PEO1/TWNK protein Bovine
GM-Tg-equg-IP10422-Ag-1/ GM-Tg-equg-IP10422-Ag-2 Equine Twinkle/PEO1/TWNK protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP10422-Ag-1/ GM-Tg-hg-IP10422-Ag-2; GM-Tg-rg-IP10422-Ag-1/ GM-Tg-rg-IP10422-Ag-2;
GM-Tg-mg-IP10422-Ag-1/ GM-Tg-mg-IP10422-Ag-2; GM-Tg-cynog-IP10422-Ag-1/ GM-Tg-cynog-IP10422-Ag-2;
GM-Tg-felg-IP10422-Ag-1/ GM-Tg-felg-IP10422-Ag-2; GM-Tg-cang-IP10422-Ag-1/ GM-Tg-cang-IP10422-Ag-2;
GM-Tg-bovg-IP10422-Ag-1/ GM-Tg-bovg-IP10422-Ag-2; GM-Tg-equg-IP10422-Ag-1/ GM-Tg-equg-IP10422-Ag-2
Products Name Twinkle/PEO1/TWNK protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Twinkle/PEO1/TWNK
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Twinkle/PEO1/TWNK protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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