Explore Twinkle/PEO1/TWNK gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Aug 2009]
| Target ID |
GM-IP10422
|
| Target Name |
Twinkle/PEO1/TWNK
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
56652
|
| Gene ID |
100070286 (Equus caballus), 101093964 (Felis catus), 226153 (Mus musculus), 309441 (Rattus norvegicus)
486845 (Canis lupus familiaris), 538467 (Bos taurus), 56652 (Homo sapiens), 710958 (Macaca mulatta)
|
| Target Alternative Names |
ATXN8,C10orf2,C1H10orf2,C26H10orf2,C28H10orf2,C9H10orf2,CD2H10orf2,D19Ertd626e,IOSCA,MTDPS7,PEO,PEO1,PEOA3,PRLTS5,Peo1,Progressive external ophthalmoplegia 1 protein,SANDO,SCA8,T7 gp4-like protein with intramitochondrial nucleoid localization,T7-like mitochondrial DNA helicase,TWINL,TWNK,Twinkle,Twinkle mtDNA helicase,Twinkle protein,Twinl,Twnk,mitochondrial,twinkle
|
| Uniprot Accession |
Q8CIW5,Q96RR1
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Gene Ensembl |
ENSECAG00000017734, ENSMUSG00000025209, ENSCAFG00845019518, ENSBTAG00000003296, ENSG00000107815, ENSMMUG00000064033
|
Twinkle/PEO1/TWNK siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo56652 | Pre-made Human TWNK/PEO/PEO1 siRNA oligo Duplex | 56652 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo309441 | Pre-made Rat Twnk/Peo1 siRNA oligo Duplex | 309441 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo226153 | Pre-made Mouse Twnk/PEO/Peo1 siRNA oligo Duplex | 226153 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710958 | Pre-made Cynomolgus/Rhesus macaque TWNK/C10orf2/C9H10orf2 siRNA oligo Duplex | 710958 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101093964 | Pre-made Cat/Feline TWNK/CD2H10orf2 siRNA oligo Duplex | 101093964 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486845 | Pre-made Dog/Canine TWNK/PEO1/C28H10orf2 siRNA oligo Duplex | 486845 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo538467 | Pre-made Bovines/Cattle TWNK/twinkle/C26H10orf2 siRNA oligo Duplex | 538467 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100070286 | Pre-made Equine/Horse TWNK/C1H10orf2 siRNA oligo Duplex | 100070286 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Twinkle/PEO1/TWNK antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP10422-Ab | Human | Anti-Human Twinkle/PEO1/TWNK monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP10422-Ab | Rat | Anti-Rat Twinkle/PEO1/TWNK monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP10422-Ab | Mouse | Anti-Mouse Twinkle/PEO1/TWNK monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP10422-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Twinkle/PEO1/TWNK monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP10422-Ab | Cat/Feline | Anti-Cat/Feline Twinkle/PEO1/TWNK monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP10422-Ab | Dog/Canine | Anti-Dog/Canine Twinkle/PEO1/TWNK monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP10422-Ab | Bovines/Cattle | Anti-Bovines/Cattle Twinkle/PEO1/TWNK monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP10422-Ab | Equine/Horse | Anti-Equine/Horse Twinkle/PEO1/TWNK monoclonal antibody | mab | | Detail |
Twinkle/PEO1/TWNK recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP10422-Ag | Human | Human Twinkle/PEO1/TWNK recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP10422-Ag | Rat | Rat Twinkle/PEO1/TWNK recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP10422-Ag | Mouse | Mouse Twinkle/PEO1/TWNK recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP10422-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Twinkle/PEO1/TWNK recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP10422-Ag | Cat/Feline | Cat/Feline Twinkle/PEO1/TWNK recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP10422-Ag | Dog/Canine | Dog/Canine Twinkle/PEO1/TWNK recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP10422-Ag | Bovines/Cattle | Bovines/Cattle Twinkle/PEO1/TWNK recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP10422-Ag | Equine/Horse | Equine/Horse Twinkle/PEO1/TWNK recombinant protein | Mammalian cell | Detail |
