Recombinant multi-species HR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
The Alternative Names of target: ALUNC,AU,HR,HSA277165,HYPT4,Hr,Lysine-specific demethylase hairless,MUHH,MUHH1,[histone H3]-dimethyl-L-lysine(9) demethylase hairless,bldy,hr,rh-bmh

Target products collectionGo to HR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP10312-Ag-1/ GM-Tg-hg-IP10312-Ag-2 Human HR protein Human
GM-Tg-rg-IP10312-Ag-1/ GM-Tg-rg-IP10312-Ag-2 Rat HR protein Rat
GM-Tg-mg-IP10312-Ag-1/ GM-Tg-mg-IP10312-Ag-2 Mouse HR protein Mouse
GM-Tg-cynog-IP10312-Ag-1/ GM-Tg-cynog-IP10312-Ag-2 Cynomolgus/Rhesus macaque HR protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP10312-Ag-1/ GM-Tg-felg-IP10312-Ag-2 Feline HR protein Feline
GM-Tg-cang-IP10312-Ag-1/ GM-Tg-cang-IP10312-Ag-2 Canine HR protein Canine
GM-Tg-bovg-IP10312-Ag-1/ GM-Tg-bovg-IP10312-Ag-2 Bovine HR protein Bovine
GM-Tg-equg-IP10312-Ag-1/ GM-Tg-equg-IP10312-Ag-2 Equine HR protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP10312-Ag-1/ GM-Tg-hg-IP10312-Ag-2; GM-Tg-rg-IP10312-Ag-1/ GM-Tg-rg-IP10312-Ag-2;
GM-Tg-mg-IP10312-Ag-1/ GM-Tg-mg-IP10312-Ag-2; GM-Tg-cynog-IP10312-Ag-1/ GM-Tg-cynog-IP10312-Ag-2;
GM-Tg-felg-IP10312-Ag-1/ GM-Tg-felg-IP10312-Ag-2; GM-Tg-cang-IP10312-Ag-1/ GM-Tg-cang-IP10312-Ag-2;
GM-Tg-bovg-IP10312-Ag-1/ GM-Tg-bovg-IP10312-Ag-2; GM-Tg-equg-IP10312-Ag-1/ GM-Tg-equg-IP10312-Ag-2
Products Name HR protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name HR
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HR protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.