Recombinant multi-species PRKCB/pan-PKC protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PRKCB/pan-PKC protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
The Alternative Names of target: PKC-B,PKC-Beta,PKC-beta,PKCB,PKCI(2),PKCbeta,PRKCB,PRKCB1,PRKCB2,Pkcb,Prkcb,Prkcb1,Prkcb2,Protein kinase C beta type,pan-PKC
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Product information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP10303-Ag-1/ GM-Tg-hg-IP10303-Ag-2 | Human PRKCB/pan-PKC protein | Human |
| GM-Tg-rg-IP10303-Ag-1/ GM-Tg-rg-IP10303-Ag-2 | Rat PRKCB/pan-PKC protein | Rat |
| GM-Tg-mg-IP10303-Ag-1/ GM-Tg-mg-IP10303-Ag-2 | Mouse PRKCB/pan-PKC protein | Mouse |
| GM-Tg-cynog-IP10303-Ag-1/ GM-Tg-cynog-IP10303-Ag-2 | Cynomolgus/Rhesus macaque PRKCB/pan-PKC protein | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP10303-Ag-1/ GM-Tg-felg-IP10303-Ag-2 | Feline PRKCB/pan-PKC protein | Feline |
| GM-Tg-cang-IP10303-Ag-1/ GM-Tg-cang-IP10303-Ag-2 | Canine PRKCB/pan-PKC protein | Canine |
| GM-Tg-bovg-IP10303-Ag-1/ GM-Tg-bovg-IP10303-Ag-2 | Bovine PRKCB/pan-PKC protein | Bovine |
| GM-Tg-equg-IP10303-Ag-1/ GM-Tg-equg-IP10303-Ag-2 | Equine PRKCB/pan-PKC protein | Equine |
Size: 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-IP10303-Ag-1/ GM-Tg-hg-IP10303-Ag-2;
GM-Tg-rg-IP10303-Ag-1/ GM-Tg-rg-IP10303-Ag-2;
GM-Tg-mg-IP10303-Ag-1/ GM-Tg-mg-IP10303-Ag-2; GM-Tg-cynog-IP10303-Ag-1/ GM-Tg-cynog-IP10303-Ag-2; GM-Tg-felg-IP10303-Ag-1/ GM-Tg-felg-IP10303-Ag-2; GM-Tg-cang-IP10303-Ag-1/ GM-Tg-cang-IP10303-Ag-2; GM-Tg-bovg-IP10303-Ag-1/ GM-Tg-bovg-IP10303-Ag-2; GM-Tg-equg-IP10303-Ag-1/ GM-Tg-equg-IP10303-Ag-2 |
| Products Name | PRKCB/pan-PKC protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | PRKCB/pan-PKC |
| Protein Sub-location | Introcelluar Protein |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PRKCB/pan-PKC protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
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pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.