Recombinant multi-species AMPK Beta 2/PRKAB2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine AMPK Beta 2/PRKAB2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
The Alternative Names of target: 5'-AMP-activated protein kinase subunit beta-2,5730553K21Rik,AMPK Beta 2,AMPK subunit beta-2,PRKAB2,Prkab2

Target products collectionGo to AMPK Beta 2/PRKAB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP10217-Ag-1/ GM-Tg-hg-IP10217-Ag-2 Human AMPK Beta 2/PRKAB2 protein Human
GM-Tg-rg-IP10217-Ag-1/ GM-Tg-rg-IP10217-Ag-2 Rat AMPK Beta 2/PRKAB2 protein Rat
GM-Tg-mg-IP10217-Ag-1/ GM-Tg-mg-IP10217-Ag-2 Mouse AMPK Beta 2/PRKAB2 protein Mouse
GM-Tg-cynog-IP10217-Ag-1/ GM-Tg-cynog-IP10217-Ag-2 Cynomolgus/Rhesus macaque AMPK Beta 2/PRKAB2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP10217-Ag-1/ GM-Tg-felg-IP10217-Ag-2 Feline AMPK Beta 2/PRKAB2 protein Feline
GM-Tg-cang-IP10217-Ag-1/ GM-Tg-cang-IP10217-Ag-2 Canine AMPK Beta 2/PRKAB2 protein Canine
GM-Tg-bovg-IP10217-Ag-1/ GM-Tg-bovg-IP10217-Ag-2 Bovine AMPK Beta 2/PRKAB2 protein Bovine
GM-Tg-equg-IP10217-Ag-1/ GM-Tg-equg-IP10217-Ag-2 Equine AMPK Beta 2/PRKAB2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP10217-Ag-1/ GM-Tg-hg-IP10217-Ag-2; GM-Tg-rg-IP10217-Ag-1/ GM-Tg-rg-IP10217-Ag-2;
GM-Tg-mg-IP10217-Ag-1/ GM-Tg-mg-IP10217-Ag-2; GM-Tg-cynog-IP10217-Ag-1/ GM-Tg-cynog-IP10217-Ag-2;
GM-Tg-felg-IP10217-Ag-1/ GM-Tg-felg-IP10217-Ag-2; GM-Tg-cang-IP10217-Ag-1/ GM-Tg-cang-IP10217-Ag-2;
GM-Tg-bovg-IP10217-Ag-1/ GM-Tg-bovg-IP10217-Ag-2; GM-Tg-equg-IP10217-Ag-1/ GM-Tg-equg-IP10217-Ag-2
Products Name AMPK Beta 2/PRKAB2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name AMPK Beta 2/PRKAB2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine AMPK Beta 2/PRKAB2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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