Explore AMPK Beta 2/PRKAB2 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
| Target ID |
GM-IP10217
|
| Target Name |
AMPK Beta 2/PRKAB2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5565
|
| Gene ID |
100034095 (Equus caballus), 100856379 (Canis lupus familiaris), 101092284 (Felis catus), 108097 (Mus musculus) 512665 (Bos taurus), 5565 (Homo sapiens), 64562 (Rattus norvegicus), 699806 (Macaca mulatta)
|
| Target Alternative Names |
5'-AMP-activated protein kinase subunit beta-2,5730553K21Rik,AMPK Beta 2,AMPK subunit beta-2,PRKAB2,Prkab2
|
| Uniprot Accession |
Q6PAM0,O43741,Q9QZH4
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Gene Ensembl |
ENSECAG00000020796, ENSCAFG00845008839, ENSMUSG00000038205, ENSBTAG00000014387, ENSG00000131791, ENSMMUG00000012221
|
Pre-made viral vector of AMPK Beta 2/PRKAB2 cDNA Clones/ORF Plasmid
AMPK Beta 2/PRKAB2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5565 | Pre-made Human PRKAB2 siRNA oligo Duplex | 5565 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo64562 | Pre-made Rat Prkab2 siRNA oligo Duplex | 64562 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo108097 | Pre-made Mouse Prkab2/5730553K21Rik siRNA oligo Duplex | 108097 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699806 | Pre-made Cynomolgus/Rhesus macaque PRKAB2 siRNA oligo Duplex | 699806 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101092284 | Pre-made Cat/Feline PRKAB2 siRNA oligo Duplex | 101092284 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100856379 | Pre-made Dog/Canine PRKAB2 siRNA oligo Duplex | 100856379 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo512665 | Pre-made Bovines/Cattle PRKAB2 siRNA oligo Duplex | 512665 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034095 | Pre-made Equine/Horse PRKAB2 siRNA oligo Duplex | 100034095 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
AMPK Beta 2/PRKAB2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP10217-Ab | Human | Anti-Human AMPK Beta 2/PRKAB2 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP10217-Ab | Rat | Anti-Rat AMPK Beta 2/PRKAB2 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP10217-Ab | Mouse | Anti-Mouse AMPK Beta 2/PRKAB2 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP10217-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque AMPK Beta 2/PRKAB2 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP10217-Ab | Cat/Feline | Anti-Cat/Feline AMPK Beta 2/PRKAB2 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP10217-Ab | Dog/Canine | Anti-Dog/Canine AMPK Beta 2/PRKAB2 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP10217-Ab | Bovines/Cattle | Anti-Bovines/Cattle AMPK Beta 2/PRKAB2 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP10217-Ab | Equine/Horse | Anti-Equine/Horse AMPK Beta 2/PRKAB2 monoclonal antibody | mab | | Detail |
AMPK Beta 2/PRKAB2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP10217-Ag | Human | Human AMPK Beta 2/PRKAB2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP10217-Ag | Rat | Rat AMPK Beta 2/PRKAB2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP10217-Ag | Mouse | Mouse AMPK Beta 2/PRKAB2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP10217-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque AMPK Beta 2/PRKAB2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP10217-Ag | Cat/Feline | Cat/Feline AMPK Beta 2/PRKAB2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP10217-Ag | Dog/Canine | Dog/Canine AMPK Beta 2/PRKAB2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP10217-Ag | Bovines/Cattle | Bovines/Cattle AMPK Beta 2/PRKAB2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP10217-Ag | Equine/Horse | Equine/Horse AMPK Beta 2/PRKAB2 recombinant protein | Mammalian cell | Detail |