Recombinant multi-species HTRA2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HTRA2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
The Alternative Names of target: HTRA2,High temperature requirement protein A2 (HtrA2),Htra2,MGCA8,OMI,Omi,Omi stress-regulated endoprotease,PARK13,PRSS25,Prss25,Serine protease 25,Serine protease HTRA2,Serine proteinase OMI,mitochondrial,mnd2

Target products collectionGo to HTRA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0992-Ag-1/ GM-Tg-hg-IP0992-Ag-2 Human HTRA2 protein Human
GM-Tg-rg-IP0992-Ag-1/ GM-Tg-rg-IP0992-Ag-2 Rat HTRA2 protein Rat
GM-Tg-mg-IP0992-Ag-1/ GM-Tg-mg-IP0992-Ag-2 Mouse HTRA2 protein Mouse
GM-Tg-cynog-IP0992-Ag-1/ GM-Tg-cynog-IP0992-Ag-2 Cynomolgus/Rhesus macaque HTRA2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0992-Ag-1/ GM-Tg-felg-IP0992-Ag-2 Feline HTRA2 protein Feline
GM-Tg-cang-IP0992-Ag-1/ GM-Tg-cang-IP0992-Ag-2 Canine HTRA2 protein Canine
GM-Tg-bovg-IP0992-Ag-1/ GM-Tg-bovg-IP0992-Ag-2 Bovine HTRA2 protein Bovine
GM-Tg-equg-IP0992-Ag-1/ GM-Tg-equg-IP0992-Ag-2 Equine HTRA2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0992-Ag-1/ GM-Tg-hg-IP0992-Ag-2; GM-Tg-rg-IP0992-Ag-1/ GM-Tg-rg-IP0992-Ag-2;
GM-Tg-mg-IP0992-Ag-1/ GM-Tg-mg-IP0992-Ag-2; GM-Tg-cynog-IP0992-Ag-1/ GM-Tg-cynog-IP0992-Ag-2;
GM-Tg-felg-IP0992-Ag-1/ GM-Tg-felg-IP0992-Ag-2; GM-Tg-cang-IP0992-Ag-1/ GM-Tg-cang-IP0992-Ag-2;
GM-Tg-bovg-IP0992-Ag-1/ GM-Tg-bovg-IP0992-Ag-2; GM-Tg-equg-IP0992-Ag-1/ GM-Tg-equg-IP0992-Ag-2
Products Name HTRA2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name HTRA2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HTRA2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.