Recombinant multi-species CLN8 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CLN8 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a transmembrane protein belonging to a family of proteins containing TLC domains, which are postulated to function in lipid synthesis, transport, or sensing. The protein localizes to the endoplasmic reticulum (ER), and may recycle between the ER and ER-Golgi intermediate compartment. Mutations in this gene are associated with a disorder characterized by progressive epilepsy with cognitive disabilities (EPMR), which is a subtype of neuronal ceroid lipofuscinoses (NCL). Patients with mutations in this gene have altered levels of sphingolipid and phospholipids in the brain. [provided by RefSeq, Jul 2017]
The Alternative Names of target: C8orf61,CLN8,Cln8,EPMR,Protein CLN8,TLCD6,Tlcd6,mnd

Target products collectionGo to CLN8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0563-Ag-1/ GM-Tg-hg-IP0563-Ag-2 Human CLN8 protein Human
GM-Tg-rg-IP0563-Ag-1/ GM-Tg-rg-IP0563-Ag-2 Rat CLN8 protein Rat
GM-Tg-mg-IP0563-Ag-1/ GM-Tg-mg-IP0563-Ag-2 Mouse CLN8 protein Mouse
GM-Tg-cynog-IP0563-Ag-1/ GM-Tg-cynog-IP0563-Ag-2 Cynomolgus/Rhesus macaque CLN8 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0563-Ag-1/ GM-Tg-felg-IP0563-Ag-2 Feline CLN8 protein Feline
GM-Tg-cang-IP0563-Ag-1/ GM-Tg-cang-IP0563-Ag-2 Canine CLN8 protein Canine
GM-Tg-bovg-IP0563-Ag-1/ GM-Tg-bovg-IP0563-Ag-2 Bovine CLN8 protein Bovine
GM-Tg-equg-IP0563-Ag-1/ GM-Tg-equg-IP0563-Ag-2 Equine CLN8 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0563-Ag-1/ GM-Tg-hg-IP0563-Ag-2; GM-Tg-rg-IP0563-Ag-1/ GM-Tg-rg-IP0563-Ag-2;
GM-Tg-mg-IP0563-Ag-1/ GM-Tg-mg-IP0563-Ag-2; GM-Tg-cynog-IP0563-Ag-1/ GM-Tg-cynog-IP0563-Ag-2;
GM-Tg-felg-IP0563-Ag-1/ GM-Tg-felg-IP0563-Ag-2; GM-Tg-cang-IP0563-Ag-1/ GM-Tg-cang-IP0563-Ag-2;
GM-Tg-bovg-IP0563-Ag-1/ GM-Tg-bovg-IP0563-Ag-2; GM-Tg-equg-IP0563-Ag-1/ GM-Tg-equg-IP0563-Ag-2
Products Name CLN8 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CLN8
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CLN8 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.