Recombinant multi-species IDH2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IDH2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
The Alternative Names of target: D2HGA2,E430004F23,ICD-M,IDH,IDH-2,IDH2,IDHM,IDP,IDPM,IDPm,Idh-2,Idh2,Isocitrate dehydrogenase [NADP],NADP(+)-specific ICDH,Oxalosuccinate decarboxylase,mNADP-IDH,mitochondrial

Target products collectionGo to IDH2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0248-Ag-1/ GM-Tg-hg-IP0248-Ag-2 Human IDH2 protein Human
GM-Tg-rg-IP0248-Ag-1/ GM-Tg-rg-IP0248-Ag-2 Rat IDH2 protein Rat
GM-Tg-mg-IP0248-Ag-1/ GM-Tg-mg-IP0248-Ag-2 Mouse IDH2 protein Mouse
GM-Tg-cynog-IP0248-Ag-1/ GM-Tg-cynog-IP0248-Ag-2 Cynomolgus/Rhesus macaque IDH2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0248-Ag-1/ GM-Tg-felg-IP0248-Ag-2 Feline IDH2 protein Feline
GM-Tg-cang-IP0248-Ag-1/ GM-Tg-cang-IP0248-Ag-2 Canine IDH2 protein Canine
GM-Tg-bovg-IP0248-Ag-1/ GM-Tg-bovg-IP0248-Ag-2 Bovine IDH2 protein Bovine
GM-Tg-equg-IP0248-Ag-1/ GM-Tg-equg-IP0248-Ag-2 Equine IDH2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0248-Ag-1/ GM-Tg-hg-IP0248-Ag-2; GM-Tg-rg-IP0248-Ag-1/ GM-Tg-rg-IP0248-Ag-2;
GM-Tg-mg-IP0248-Ag-1/ GM-Tg-mg-IP0248-Ag-2; GM-Tg-cynog-IP0248-Ag-1/ GM-Tg-cynog-IP0248-Ag-2;
GM-Tg-felg-IP0248-Ag-1/ GM-Tg-felg-IP0248-Ag-2; GM-Tg-cang-IP0248-Ag-1/ GM-Tg-cang-IP0248-Ag-2;
GM-Tg-bovg-IP0248-Ag-1/ GM-Tg-bovg-IP0248-Ag-2; GM-Tg-equg-IP0248-Ag-1/ GM-Tg-equg-IP0248-Ag-2
Products Name IDH2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IDH2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IDH2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.