Recombinant multi-species BAK/BAK1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BAK/BAK1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]
The Alternative Names of target: Apoptosis regulator BAK,BAK,BAK-LIKE,BAK1,BCL2L7,Bak,Bak1,Bcl-2 homologous antagonist/killer,Bcl-2-like protein 7 (Bcl2-L-7),CDN1,N-BAK1,N-Bak

Target products collectionGo to BAK/BAK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0150-Ag-1/ GM-Tg-hg-IP0150-Ag-2 Human BAK/BAK1 protein Human
GM-Tg-rg-IP0150-Ag-1/ GM-Tg-rg-IP0150-Ag-2 Rat BAK/BAK1 protein Rat
GM-Tg-mg-IP0150-Ag-1/ GM-Tg-mg-IP0150-Ag-2 Mouse BAK/BAK1 protein Mouse
GM-Tg-cynog-IP0150-Ag-1/ GM-Tg-cynog-IP0150-Ag-2 Cynomolgus/Rhesus macaque BAK/BAK1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0150-Ag-1/ GM-Tg-felg-IP0150-Ag-2 Feline BAK/BAK1 protein Feline
GM-Tg-cang-IP0150-Ag-1/ GM-Tg-cang-IP0150-Ag-2 Canine BAK/BAK1 protein Canine
GM-Tg-bovg-IP0150-Ag-1/ GM-Tg-bovg-IP0150-Ag-2 Bovine BAK/BAK1 protein Bovine
GM-Tg-equg-IP0150-Ag-1/ GM-Tg-equg-IP0150-Ag-2 Equine BAK/BAK1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0150-Ag-1/ GM-Tg-hg-IP0150-Ag-2; GM-Tg-rg-IP0150-Ag-1/ GM-Tg-rg-IP0150-Ag-2;
GM-Tg-mg-IP0150-Ag-1/ GM-Tg-mg-IP0150-Ag-2; GM-Tg-cynog-IP0150-Ag-1/ GM-Tg-cynog-IP0150-Ag-2;
GM-Tg-felg-IP0150-Ag-1/ GM-Tg-felg-IP0150-Ag-2; GM-Tg-cang-IP0150-Ag-1/ GM-Tg-cang-IP0150-Ag-2;
GM-Tg-bovg-IP0150-Ag-1/ GM-Tg-bovg-IP0150-Ag-2; GM-Tg-equg-IP0150-Ag-1/ GM-Tg-equg-IP0150-Ag-2
Products Name BAK/BAK1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name BAK/BAK1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BAK/BAK1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.