Recombinant multi-species PTGIS protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PTGIS protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
The Alternative Names of target: CYP8,CYP8A1,Cyp8,Cyp8a1,Hydroperoxy icosatetraenoate dehydratase,PGIS,PTGI,PTGIS,Pgis,Prostacyclin synthase,Prostaglandin I2 synthase,Ptgis

Target products collectionGo to PTGIS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0125-Ag-1/ GM-Tg-hg-IP0125-Ag-2 Human PTGIS protein Human
GM-Tg-rg-IP0125-Ag-1/ GM-Tg-rg-IP0125-Ag-2 Rat PTGIS protein Rat
GM-Tg-mg-IP0125-Ag-1/ GM-Tg-mg-IP0125-Ag-2 Mouse PTGIS protein Mouse
GM-Tg-cynog-IP0125-Ag-1/ GM-Tg-cynog-IP0125-Ag-2 Cynomolgus/Rhesus macaque PTGIS protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0125-Ag-1/ GM-Tg-felg-IP0125-Ag-2 Feline PTGIS protein Feline
GM-Tg-cang-IP0125-Ag-1/ GM-Tg-cang-IP0125-Ag-2 Canine PTGIS protein Canine
GM-Tg-bovg-IP0125-Ag-1/ GM-Tg-bovg-IP0125-Ag-2 Bovine PTGIS protein Bovine
GM-Tg-equg-IP0125-Ag-1/ GM-Tg-equg-IP0125-Ag-2 Equine PTGIS protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0125-Ag-1/ GM-Tg-hg-IP0125-Ag-2; GM-Tg-rg-IP0125-Ag-1/ GM-Tg-rg-IP0125-Ag-2;
GM-Tg-mg-IP0125-Ag-1/ GM-Tg-mg-IP0125-Ag-2; GM-Tg-cynog-IP0125-Ag-1/ GM-Tg-cynog-IP0125-Ag-2;
GM-Tg-felg-IP0125-Ag-1/ GM-Tg-felg-IP0125-Ag-2; GM-Tg-cang-IP0125-Ag-1/ GM-Tg-cang-IP0125-Ag-2;
GM-Tg-bovg-IP0125-Ag-1/ GM-Tg-bovg-IP0125-Ag-2; GM-Tg-equg-IP0125-Ag-1/ GM-Tg-equg-IP0125-Ag-2
Products Name PTGIS protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PTGIS
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PTGIS protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.