PTGIS Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore PTGIS gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Introcelluar Protein.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]

Target ID GM-IP0125
Target Name PTGIS
Gene Group ldentifer
(Target Gene ID in Homo species)
5740
Gene ID 100071412 (Equus caballus), 100856661 (Canis lupus familiaris), 101082050 (Felis catus), 19223 (Mus musculus)
25527 (Rattus norvegicus), 282021 (Bos taurus), 5740 (Homo sapiens), 703407 (Macaca mulatta)
Target Alternative Names CYP8,CYP8A1,Cyp8,Cyp8a1,Hydroperoxy icosatetraenoate dehydratase,PGIS,PTGI,PTGIS,Pgis,Prostacyclin synthase,Prostaglandin I2 synthase,Ptgis
Uniprot Accession O35074,Q62969,Q29626,Q16647
Protein Sub-location Introcelluar Protein
Category Therapeutics Target
Disease from KEGG Metabolic pathways, Arachidonic acid metabolism
Gene Ensembl ENSECAG00000016521, ENSCAFG00845025000, ENSMUSG00000017969, ENSBTAG00000017537, ENSG00000124212, ENSMMUG00000021692


Pre-made viral vector of PTGIS cDNA Clones/ORF Plasmid

Cat No.Product NameNMIDGeneIDSpeciesTypeMarkerFusion TagPromoterDetail
pGMLV002451Human PTGIS/CYP8/CYP8A1 Lentivirus plasmidNM_000961.45740HumanLentivirus plasmidNull3xflag (C-Terminal)CMVDetail
vGMLV002451Human PTGIS/CYP8/CYP8A1 Lentivirus particleNM_000961.45740HumanLentivirus particleNull3xflag (C-Terminal)CMVDetail
pGMLV002168Mouse Ptgis/Cyp8/Cyp8a1 Lentivirus plasmidNM_008968.419223MouseLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMAAV000437Mouse Ptgis/Cyp8/Cyp8a1 Adeno-associate virus(AAV) plasmidNM_008968.419223MouseAdeno-associate virus(AAV) plasmidZsGreen3xflag (C-Terminal)CMVDetail
vGMLV002168Mouse Ptgis/Cyp8/Cyp8a1 Lentivirus particleNM_008968.419223MouseLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMAAV000437Mouse Ptgis/Cyp8/Cyp8a1 Adeno-associate virus(AAV) particleNM_008968.419223MouseAdeno-associate virus(AAV) particleZsGreen3xflag (C-Terminal)CMVDetail


PTGIS siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.Product NameGeneIDSpeciesGradeDetail
pGMoligo5740Pre-made Human PTGIS/CYP8/PGIS siRNA oligo Duplex5740HumanIn-vitro grade; in-vivo gradeDetail
pGMoligo25527Pre-made Rat Ptgis/PGIS siRNA oligo Duplex25527RatIn-vitro grade; in-vivo gradeDetail
pGMoligo19223Pre-made Mouse Ptgis/Cyp8/Pgis siRNA oligo Duplex19223MouseIn-vitro grade; in-vivo gradeDetail
pGMoligo703407Pre-made Cynomolgus/Rhesus macaque PTGIS siRNA oligo Duplex703407Cynomolgus/Rhesus macaqueIn-vitro grade; in-vivo gradeDetail
pGMoligo101082050Pre-made Cat/Feline PTGIS siRNA oligo Duplex101082050Cat/FelineIn-vitro grade; in-vivo gradeDetail
pGMoligo100856661Pre-made Dog/Canine PTGIS siRNA oligo Duplex100856661Dog/CanineIn-vitro grade; in-vivo gradeDetail
pGMoligo282021Pre-made Bovines/Cattle PTGIS siRNA oligo Duplex282021Bovines/CattleIn-vitro grade; in-vivo gradeDetail
pGMoligo100071412Pre-made Equine/Horse PTGIS siRNA oligo Duplex100071412Equine/HorseIn-vitro grade; in-vivo gradeDetail


PTGIS antibody/GMab

Cat No.SpeciesAntibody NameFormatClassified by tagDetail
GM-Tg-hg-IP0125-AbHumanAnti-Human PTGIS monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-rg-IP0125-AbRatAnti-Rat PTGIS monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-mg-IP0125-AbMouseAnti-Mouse PTGIS monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-cynog-IP0125-AbCynomolgus/Rhesus macaqueAnti-Cynomolgus/Rhesus macaque PTGIS monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-felg-IP0125-AbCat/FelineAnti-Cat/Feline PTGIS monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-cang-IP0125-AbDog/CanineAnti-Dog/Canine PTGIS monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-bovg-IP0125-AbBovines/CattleAnti-Bovines/Cattle PTGIS monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-equg-IP0125-AbEquine/HorseAnti-Equine/Horse PTGIS monoclonal antibodymabTherapeutics Target antibodyDetail


PTGIS recombinant protein

Cat No.SpeciesAntigen NameExpression PlatformDetail
GM-Tg-hg-IP0125-AgHumanHuman PTGIS recombinant proteinMammalian cellDetail
GM-Tg-rg-IP0125-AgRatRat PTGIS recombinant proteinMammalian cellDetail
GM-Tg-mg-IP0125-AgMouseMouse PTGIS recombinant proteinMammalian cellDetail
GM-Tg-cynog-IP0125-AgCynomolgus/Rhesus macaqueCynomolgus/Rhesus macaque PTGIS recombinant proteinMammalian cellDetail
GM-Tg-felg-IP0125-AgCat/FelineCat/Feline PTGIS recombinant proteinMammalian cellDetail
GM-Tg-cang-IP0125-AgDog/CanineDog/Canine PTGIS recombinant proteinMammalian cellDetail
GM-Tg-bovg-IP0125-AgBovines/CattleBovines/Cattle PTGIS recombinant proteinMammalian cellDetail
GM-Tg-equg-IP0125-AgEquine/HorseEquine/Horse PTGIS recombinant proteinMammalian cellDetail