Explore PTGIS gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
| Target ID |
GM-IP0125
|
| Target Name |
PTGIS
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5740
|
| Gene ID |
100071412 (Equus caballus), 100856661 (Canis lupus familiaris), 101082050 (Felis catus), 19223 (Mus musculus) 25527 (Rattus norvegicus), 282021 (Bos taurus), 5740 (Homo sapiens), 703407 (Macaca mulatta)
|
| Target Alternative Names |
CYP8,CYP8A1,Cyp8,Cyp8a1,Hydroperoxy icosatetraenoate dehydratase,PGIS,PTGI,PTGIS,Pgis,Prostacyclin synthase,Prostaglandin I2 synthase,Ptgis
|
| Uniprot Accession |
O35074,Q62969,Q29626,Q16647
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways, Arachidonic acid metabolism
|
| Gene Ensembl |
ENSECAG00000016521, ENSCAFG00845025000, ENSMUSG00000017969, ENSBTAG00000017537, ENSG00000124212, ENSMMUG00000021692
|
Pre-made viral vector of PTGIS cDNA Clones/ORF Plasmid
PTGIS siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5740 | Pre-made Human PTGIS/CYP8/PGIS siRNA oligo Duplex | 5740 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25527 | Pre-made Rat Ptgis/PGIS siRNA oligo Duplex | 25527 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19223 | Pre-made Mouse Ptgis/Cyp8/Pgis siRNA oligo Duplex | 19223 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703407 | Pre-made Cynomolgus/Rhesus macaque PTGIS siRNA oligo Duplex | 703407 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082050 | Pre-made Cat/Feline PTGIS siRNA oligo Duplex | 101082050 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100856661 | Pre-made Dog/Canine PTGIS siRNA oligo Duplex | 100856661 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282021 | Pre-made Bovines/Cattle PTGIS siRNA oligo Duplex | 282021 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100071412 | Pre-made Equine/Horse PTGIS siRNA oligo Duplex | 100071412 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PTGIS antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0125-Ab | Human | Anti-Human PTGIS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0125-Ab | Rat | Anti-Rat PTGIS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0125-Ab | Mouse | Anti-Mouse PTGIS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0125-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PTGIS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0125-Ab | Cat/Feline | Anti-Cat/Feline PTGIS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0125-Ab | Dog/Canine | Anti-Dog/Canine PTGIS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0125-Ab | Bovines/Cattle | Anti-Bovines/Cattle PTGIS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0125-Ab | Equine/Horse | Anti-Equine/Horse PTGIS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PTGIS recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0125-Ag | Human | Human PTGIS recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0125-Ag | Rat | Rat PTGIS recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0125-Ag | Mouse | Mouse PTGIS recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0125-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PTGIS recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0125-Ag | Cat/Feline | Cat/Feline PTGIS recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0125-Ag | Dog/Canine | Dog/Canine PTGIS recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0125-Ag | Bovines/Cattle | Bovines/Cattle PTGIS recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0125-Ag | Equine/Horse | Equine/Horse PTGIS recombinant protein | Mammalian cell | Detail |