Recombinant multi-species ATP2A2/SERCA2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ATP2A2/SERCA2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019]
The Alternative Names of target: 9530097L16Rik,ATP2A2,ATP2B,Atp2a2,Calcium pump 2,Calcium-transporting ATPase sarcoplasmic reticulum type,D5Wsu150e,DAR,DD,Endoplasmic reticulum class 1/2 Ca(2+) ATPase,SERCA2,SERCA2A,SERCA2B,SR Ca(2+)-ATPase 2,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,Serca2,Serca2a,SercaII,mKIAA4195,slow twitch skeletal muscle isoform

Target products collectionGo to ATP2A2/SERCA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0055-Ag-1/ GM-Tg-hg-IP0055-Ag-2 Human ATP2A2/SERCA2 protein Human
GM-Tg-rg-IP0055-Ag-1/ GM-Tg-rg-IP0055-Ag-2 Rat ATP2A2/SERCA2 protein Rat
GM-Tg-mg-IP0055-Ag-1/ GM-Tg-mg-IP0055-Ag-2 Mouse ATP2A2/SERCA2 protein Mouse
GM-Tg-cynog-IP0055-Ag-1/ GM-Tg-cynog-IP0055-Ag-2 Cynomolgus/Rhesus macaque ATP2A2/SERCA2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0055-Ag-1/ GM-Tg-felg-IP0055-Ag-2 Feline ATP2A2/SERCA2 protein Feline
GM-Tg-cang-IP0055-Ag-1/ GM-Tg-cang-IP0055-Ag-2 Canine ATP2A2/SERCA2 protein Canine
GM-Tg-bovg-IP0055-Ag-1/ GM-Tg-bovg-IP0055-Ag-2 Bovine ATP2A2/SERCA2 protein Bovine
GM-Tg-equg-IP0055-Ag-1/ GM-Tg-equg-IP0055-Ag-2 Equine ATP2A2/SERCA2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0055-Ag-1/ GM-Tg-hg-IP0055-Ag-2; GM-Tg-rg-IP0055-Ag-1/ GM-Tg-rg-IP0055-Ag-2;
GM-Tg-mg-IP0055-Ag-1/ GM-Tg-mg-IP0055-Ag-2; GM-Tg-cynog-IP0055-Ag-1/ GM-Tg-cynog-IP0055-Ag-2;
GM-Tg-felg-IP0055-Ag-1/ GM-Tg-felg-IP0055-Ag-2; GM-Tg-cang-IP0055-Ag-1/ GM-Tg-cang-IP0055-Ag-2;
GM-Tg-bovg-IP0055-Ag-1/ GM-Tg-bovg-IP0055-Ag-2; GM-Tg-equg-IP0055-Ag-1/ GM-Tg-equg-IP0055-Ag-2
Products Name ATP2A2/SERCA2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ATP2A2/SERCA2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ATP2A2/SERCA2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.