Explore ATP2A2/SERCA2 gene products and cross-species
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Target
sublocation: Introcelluar Protein.
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019]
| Target ID |
GM-IP0055
|
| Target Name |
ATP2A2/SERCA2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
488
|
| Gene ID |
11938 (Mus musculus), 29693 (Rattus norvegicus), 403878 (Canis lupus familiaris), 488 (Homo sapiens) 493691 (Felis catus), 540568 (Bos taurus), 710702 (Macaca mulatta), 791242 (Equus caballus)
|
| Target Alternative Names |
9530097L16Rik,ATP2A2,ATP2B,Atp2a2,Calcium pump 2,Calcium-transporting ATPase sarcoplasmic reticulum type,D5Wsu150e,DAR,DD,Endoplasmic reticulum class 1/2 Ca(2+) ATPase,SERCA2,SERCA2A,SERCA2B,SR Ca(2+)-ATPase 2,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,Serca2,Serca2a,SercaII,mKIAA4195,slow twitch skeletal muscle isoform
|
| Uniprot Accession |
O55143,P11507,O46674,P16615,Q00779
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Adrenergic signaling in cardiomyocytes, Thyroid hormone signaling pathway, Pancreatic secretion, Alzheimer disease, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy
|
| Gene Ensembl |
ENSMUSG00000029467, ENSCAFG00845027628, ENSG00000174437, ENSBTAG00000001398, ENSMMUG00000001739, ENSECAG00000007671
|
Pre-made viral vector of ATP2A2/SERCA2 cDNA Clones/ORF Plasmid
ATP2A2/SERCA2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo488 | Pre-made Human ATP2A2/DD/DAR siRNA oligo Duplex | 488 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29693 | Pre-made Rat Atp2a2/Serca2/SercaII siRNA oligo Duplex | 29693 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11938 | Pre-made Mouse Atp2a2/SERCA2/SERCA2B siRNA oligo Duplex | 11938 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710702 | Pre-made Cynomolgus/Rhesus macaque ATP2A2 siRNA oligo Duplex | 710702 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493691 | Pre-made Cat/Feline ATP2A2/SERCA2 siRNA oligo Duplex | 493691 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403878 | Pre-made Dog/Canine ATP2A2/SERCA2A siRNA oligo Duplex | 403878 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo540568 | Pre-made Bovines/Cattle ATP2A2 siRNA oligo Duplex | 540568 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo791242 | Pre-made Equine/Horse ATP2A2 siRNA oligo Duplex | 791242 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ATP2A2/SERCA2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0055-Ab | Human | Anti-Human ATP2A2/SERCA2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0055-Ab | Rat | Anti-Rat ATP2A2/SERCA2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0055-Ab | Mouse | Anti-Mouse ATP2A2/SERCA2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0055-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ATP2A2/SERCA2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0055-Ab | Cat/Feline | Anti-Cat/Feline ATP2A2/SERCA2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0055-Ab | Dog/Canine | Anti-Dog/Canine ATP2A2/SERCA2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0055-Ab | Bovines/Cattle | Anti-Bovines/Cattle ATP2A2/SERCA2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0055-Ab | Equine/Horse | Anti-Equine/Horse ATP2A2/SERCA2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
ATP2A2/SERCA2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0055-Ag | Human | Human ATP2A2/SERCA2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0055-Ag | Rat | Rat ATP2A2/SERCA2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0055-Ag | Mouse | Mouse ATP2A2/SERCA2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0055-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ATP2A2/SERCA2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0055-Ag | Cat/Feline | Cat/Feline ATP2A2/SERCA2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0055-Ag | Dog/Canine | Dog/Canine ATP2A2/SERCA2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0055-Ag | Bovines/Cattle | Bovines/Cattle ATP2A2/SERCA2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0055-Ag | Equine/Horse | Equine/Horse ATP2A2/SERCA2 recombinant protein | Mammalian cell | Detail |