Recombinant multi-species ATM protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ATM protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
The Alternative Names of target: AT1,ATA,ATC,ATD,ATDC,ATE,ATM,Ataxia telangiectasia mutated (A-T mutated),Atm,C030026E19Rik,Serine-protein kinase ATM,TEL1,TELO1

Target products collectionGo to ATM products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0050-Ag-1/ GM-Tg-hg-IP0050-Ag-2 Human ATM protein Human
GM-Tg-rg-IP0050-Ag-1/ GM-Tg-rg-IP0050-Ag-2 Rat ATM protein Rat
GM-Tg-mg-IP0050-Ag-1/ GM-Tg-mg-IP0050-Ag-2 Mouse ATM protein Mouse
GM-Tg-cynog-IP0050-Ag-1/ GM-Tg-cynog-IP0050-Ag-2 Cynomolgus/Rhesus macaque ATM protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0050-Ag-1/ GM-Tg-felg-IP0050-Ag-2 Feline ATM protein Feline
GM-Tg-cang-IP0050-Ag-1/ GM-Tg-cang-IP0050-Ag-2 Canine ATM protein Canine
GM-Tg-bovg-IP0050-Ag-1/ GM-Tg-bovg-IP0050-Ag-2 Bovine ATM protein Bovine
GM-Tg-equg-IP0050-Ag-1/ GM-Tg-equg-IP0050-Ag-2 Equine ATM protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0050-Ag-1/ GM-Tg-hg-IP0050-Ag-2; GM-Tg-rg-IP0050-Ag-1/ GM-Tg-rg-IP0050-Ag-2;
GM-Tg-mg-IP0050-Ag-1/ GM-Tg-mg-IP0050-Ag-2; GM-Tg-cynog-IP0050-Ag-1/ GM-Tg-cynog-IP0050-Ag-2;
GM-Tg-felg-IP0050-Ag-1/ GM-Tg-felg-IP0050-Ag-2; GM-Tg-cang-IP0050-Ag-1/ GM-Tg-cang-IP0050-Ag-2;
GM-Tg-bovg-IP0050-Ag-1/ GM-Tg-bovg-IP0050-Ag-2; GM-Tg-equg-IP0050-Ag-1/ GM-Tg-equg-IP0050-Ag-2
Products Name ATM protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ATM
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ATM protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.