Explore ATM gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
| Target ID |
GM-IP0050
|
| Target Name |
ATM
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
472
|
| Gene ID |
100061765 (Equus caballus), 100427400 (Macaca mulatta), 101089291 (Felis catus), 11920 (Mus musculus)
300711 (Rattus norvegicus), 472 (Homo sapiens), 479450 (Canis lupus familiaris), 526824 (Bos taurus)
|
| Target Alternative Names |
AT1,ATA,ATC,ATD,ATDC,ATE,ATM,Ataxia telangiectasia mutated (A-T mutated),Atm,C030026E19Rik,Serine-protein kinase ATM,TEL1,TELO1
|
| Uniprot Accession |
Q62388,Q13315
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
NF-kappa B signaling pathway, FoxO signaling pathway, p53 signaling pathway, Apoptosis, Cellular senescence, Human papillomavirus infection, Human T-cell leukemia virus 1 infection
|
| Gene Ensembl |
ENSECAG00000021147, ENSMMUG00000004153, ENSMUSG00000034218, ENSG00000149311, ENSCAFG00845003472, ENSBTAG00000003111
|
| Target Classification |
Kinase, Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of ATM cDNA Clones/ORF Plasmid
ATM siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo472 | Pre-made Human ATM/AT1/ATA siRNA oligo Duplex | 472 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo300711 | Pre-made Rat Atm siRNA oligo Duplex | 300711 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11920 | Pre-made Mouse Atm/C030026E19Rik siRNA oligo Duplex | 11920 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100427400 | Pre-made Cynomolgus/Rhesus macaque ATM siRNA oligo Duplex | 100427400 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101089291 | Pre-made Cat/Feline ATM siRNA oligo Duplex | 101089291 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo479450 | Pre-made Dog/Canine ATM siRNA oligo Duplex | 479450 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo526824 | Pre-made Bovines/Cattle ATM siRNA oligo Duplex | 526824 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100061765 | Pre-made Equine/Horse ATM siRNA oligo Duplex | 100061765 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ATM antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0050-Ab | Human | Anti-Human ATM monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0050-Ab | Rat | Anti-Rat ATM monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0050-Ab | Mouse | Anti-Mouse ATM monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0050-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ATM monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0050-Ab | Cat/Feline | Anti-Cat/Feline ATM monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0050-Ab | Dog/Canine | Anti-Dog/Canine ATM monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0050-Ab | Bovines/Cattle | Anti-Bovines/Cattle ATM monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0050-Ab | Equine/Horse | Anti-Equine/Horse ATM monoclonal antibody | mab | Therapeutics Target antibody | Detail |
ATM recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0050-Ag | Human | Human ATM recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0050-Ag | Rat | Rat ATM recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0050-Ag | Mouse | Mouse ATM recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0050-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ATM recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0050-Ag | Cat/Feline | Cat/Feline ATM recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0050-Ag | Dog/Canine | Dog/Canine ATM recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0050-Ag | Bovines/Cattle | Bovines/Cattle ATM recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0050-Ag | Equine/Horse | Equine/Horse ATM recombinant protein | Mammalian cell | Detail |
