Recombinant multi-species MCL1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MCL1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
The Alternative Names of target: BCL2L3,Bcl-2-like protein 3 (Bcl2-L-3),Bcl-2-related protein EAT/mcl1,EAT,Gm52627,Induced myeloid leukemia cell differentiation protein Mcl-1,MCL1,MCL1-ES,MCL1L,MCL1S,Mcl-1,Mcl1,TM,bcl2-L-3,mcl-1,mcl1/EAT

Target products collectionGo to MCL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0049-Ag-1/ GM-Tg-hg-IP0049-Ag-2 Human MCL1 protein Human
GM-Tg-rg-IP0049-Ag-1/ GM-Tg-rg-IP0049-Ag-2 Rat MCL1 protein Rat
GM-Tg-mg-IP0049-Ag-1/ GM-Tg-mg-IP0049-Ag-2 Mouse MCL1 protein Mouse
GM-Tg-cynog-IP0049-Ag-1/ GM-Tg-cynog-IP0049-Ag-2 Cynomolgus/Rhesus macaque MCL1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0049-Ag-1/ GM-Tg-felg-IP0049-Ag-2 Feline MCL1 protein Feline
GM-Tg-cang-IP0049-Ag-1/ GM-Tg-cang-IP0049-Ag-2 Canine MCL1 protein Canine
GM-Tg-bovg-IP0049-Ag-1/ GM-Tg-bovg-IP0049-Ag-2 Bovine MCL1 protein Bovine
GM-Tg-equg-IP0049-Ag-1/ GM-Tg-equg-IP0049-Ag-2 Equine MCL1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0049-Ag-1/ GM-Tg-hg-IP0049-Ag-2; GM-Tg-rg-IP0049-Ag-1/ GM-Tg-rg-IP0049-Ag-2;
GM-Tg-mg-IP0049-Ag-1/ GM-Tg-mg-IP0049-Ag-2; GM-Tg-cynog-IP0049-Ag-1/ GM-Tg-cynog-IP0049-Ag-2;
GM-Tg-felg-IP0049-Ag-1/ GM-Tg-felg-IP0049-Ag-2; GM-Tg-cang-IP0049-Ag-1/ GM-Tg-cang-IP0049-Ag-2;
GM-Tg-bovg-IP0049-Ag-1/ GM-Tg-bovg-IP0049-Ag-2; GM-Tg-equg-IP0049-Ag-1/ GM-Tg-equg-IP0049-Ag-2
Products Name MCL1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MCL1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MCL1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.