Recombinant multi-species Bcl-XL/Bcl-xL/BCL2L1/BCL-xL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Bcl-XL/Bcl-xL/BCL2L1/BCL-xL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]
The Alternative Names of target: Apoptosis regulator Bcl-X,BCL-XL,BCL-XL/S,BCL-xL,BCL2L,BCL2L1,BCLX,Bcl(X)L,Bcl-2-like protein 1,Bcl-X,Bcl-XL,Bcl-xL,Bcl-xl,Bcl2-L-1,Bcl2l,Bcl2l1,BclX,Bclx,PPP1R52,bcl-X,bcl-x,bcl-xl,bcl2-L-1

Target products collectionGo to Bcl-XL/Bcl-xL/BCL2L1/BCL-xL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0048-Ag-1/ GM-Tg-hg-IP0048-Ag-2 Human Bcl-XL/Bcl-xL/BCL2L1/BCL-xL protein Human
GM-Tg-rg-IP0048-Ag-1/ GM-Tg-rg-IP0048-Ag-2 Rat Bcl-XL/Bcl-xL/BCL2L1/BCL-xL protein Rat
GM-Tg-mg-IP0048-Ag-1/ GM-Tg-mg-IP0048-Ag-2 Mouse Bcl-XL/Bcl-xL/BCL2L1/BCL-xL protein Mouse
GM-Tg-cynog-IP0048-Ag-1/ GM-Tg-cynog-IP0048-Ag-2 Cynomolgus/Rhesus macaque Bcl-XL/Bcl-xL/BCL2L1/BCL-xL protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0048-Ag-1/ GM-Tg-felg-IP0048-Ag-2 Feline Bcl-XL/Bcl-xL/BCL2L1/BCL-xL protein Feline
GM-Tg-cang-IP0048-Ag-1/ GM-Tg-cang-IP0048-Ag-2 Canine Bcl-XL/Bcl-xL/BCL2L1/BCL-xL protein Canine
GM-Tg-bovg-IP0048-Ag-1/ GM-Tg-bovg-IP0048-Ag-2 Bovine Bcl-XL/Bcl-xL/BCL2L1/BCL-xL protein Bovine
GM-Tg-equg-IP0048-Ag-1/ GM-Tg-equg-IP0048-Ag-2 Equine Bcl-XL/Bcl-xL/BCL2L1/BCL-xL protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0048-Ag-1/ GM-Tg-hg-IP0048-Ag-2; GM-Tg-rg-IP0048-Ag-1/ GM-Tg-rg-IP0048-Ag-2;
GM-Tg-mg-IP0048-Ag-1/ GM-Tg-mg-IP0048-Ag-2; GM-Tg-cynog-IP0048-Ag-1/ GM-Tg-cynog-IP0048-Ag-2;
GM-Tg-felg-IP0048-Ag-1/ GM-Tg-felg-IP0048-Ag-2; GM-Tg-cang-IP0048-Ag-1/ GM-Tg-cang-IP0048-Ag-2;
GM-Tg-bovg-IP0048-Ag-1/ GM-Tg-bovg-IP0048-Ag-2; GM-Tg-equg-IP0048-Ag-1/ GM-Tg-equg-IP0048-Ag-2
Products Name Bcl-XL/Bcl-xL/BCL2L1/BCL-xL protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Bcl-XL/Bcl-xL/BCL2L1/BCL-xL
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Bcl-XL/Bcl-xL/BCL2L1/BCL-xL protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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