Recombinant multi-species PDE4B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PDE4B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
The Alternative Names of target: 3',5'-cyclic-AMP phosphodiesterase 4B,DPDE4,Dpde4,PDE32,PDE4/IVb,PDE4B,PDEIVB,Pde4B1,Pde4B2,Pde4B3,Pde4B4,Pde4b,Pde4b5,Pde4b_v1,Pde4b_v2,Pde4b_v3,Pde4b_v4,cAMP-specific phosphodiesterase 4B,dunce

Target products collectionGo to PDE4B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0041-Ag-1/ GM-Tg-hg-IP0041-Ag-2 Human PDE4B protein Human
GM-Tg-rg-IP0041-Ag-1/ GM-Tg-rg-IP0041-Ag-2 Rat PDE4B protein Rat
GM-Tg-mg-IP0041-Ag-1/ GM-Tg-mg-IP0041-Ag-2 Mouse PDE4B protein Mouse
GM-Tg-cynog-IP0041-Ag-1/ GM-Tg-cynog-IP0041-Ag-2 Cynomolgus/Rhesus macaque PDE4B protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0041-Ag-1/ GM-Tg-felg-IP0041-Ag-2 Feline PDE4B protein Feline
GM-Tg-cang-IP0041-Ag-1/ GM-Tg-cang-IP0041-Ag-2 Canine PDE4B protein Canine
GM-Tg-bovg-IP0041-Ag-1/ GM-Tg-bovg-IP0041-Ag-2 Bovine PDE4B protein Bovine
GM-Tg-equg-IP0041-Ag-1/ GM-Tg-equg-IP0041-Ag-2 Equine PDE4B protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0041-Ag-1/ GM-Tg-hg-IP0041-Ag-2; GM-Tg-rg-IP0041-Ag-1/ GM-Tg-rg-IP0041-Ag-2;
GM-Tg-mg-IP0041-Ag-1/ GM-Tg-mg-IP0041-Ag-2; GM-Tg-cynog-IP0041-Ag-1/ GM-Tg-cynog-IP0041-Ag-2;
GM-Tg-felg-IP0041-Ag-1/ GM-Tg-felg-IP0041-Ag-2; GM-Tg-cang-IP0041-Ag-1/ GM-Tg-cang-IP0041-Ag-2;
GM-Tg-bovg-IP0041-Ag-1/ GM-Tg-bovg-IP0041-Ag-2; GM-Tg-equg-IP0041-Ag-1/ GM-Tg-equg-IP0041-Ag-2
Products Name PDE4B protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PDE4B
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PDE4B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.