Recombinant multi-species CYP3A4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CYP3A4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, erythromycin, and chloroquine. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2020]
The Alternative Names of target: 1,4-cineole 2-exo-monooxygenase,8-cineole 2-exo-monooxygenase,Albendazole monooxygenase (sulfoxide-forming),Albendazole sulfoxidase,CP33,CP34,CYP3A,CYP3A3,CYP3A4,CYPIIIA3,CYPIIIA4,Cholesterol 25-hydroxylase,Cytochrome P450 3A3,Cytochrome P450 3A4,Cytochrome P450 HLp,Cytochrome P450 NF-25,Cytochrome P450-PCN1,HLP,NF-25,Nifedipine oxidase,P450C3,P450PCN1,Quinine 3-monooxygenase,VDDR3

Target products collectionGo to CYP3A4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0038-Ag-1/ GM-Tg-hg-IP0038-Ag-2 Human CYP3A4 protein Human
GM-Tg-rg-IP0038-Ag-1/ GM-Tg-rg-IP0038-Ag-2 Rat CYP3A4 protein Rat
GM-Tg-mg-IP0038-Ag-1/ GM-Tg-mg-IP0038-Ag-2 Mouse CYP3A4 protein Mouse
GM-Tg-cynog-IP0038-Ag-1/ GM-Tg-cynog-IP0038-Ag-2 Cynomolgus/Rhesus macaque CYP3A4 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0038-Ag-1/ GM-Tg-felg-IP0038-Ag-2 Feline CYP3A4 protein Feline
GM-Tg-cang-IP0038-Ag-1/ GM-Tg-cang-IP0038-Ag-2 Canine CYP3A4 protein Canine
GM-Tg-bovg-IP0038-Ag-1/ GM-Tg-bovg-IP0038-Ag-2 Bovine CYP3A4 protein Bovine
GM-Tg-equg-IP0038-Ag-1/ GM-Tg-equg-IP0038-Ag-2 Equine CYP3A4 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0038-Ag-1/ GM-Tg-hg-IP0038-Ag-2; GM-Tg-rg-IP0038-Ag-1/ GM-Tg-rg-IP0038-Ag-2;
GM-Tg-mg-IP0038-Ag-1/ GM-Tg-mg-IP0038-Ag-2; GM-Tg-cynog-IP0038-Ag-1/ GM-Tg-cynog-IP0038-Ag-2;
GM-Tg-felg-IP0038-Ag-1/ GM-Tg-felg-IP0038-Ag-2; GM-Tg-cang-IP0038-Ag-1/ GM-Tg-cang-IP0038-Ag-2;
GM-Tg-bovg-IP0038-Ag-1/ GM-Tg-bovg-IP0038-Ag-2; GM-Tg-equg-IP0038-Ag-1/ GM-Tg-equg-IP0038-Ag-2
Products Name CYP3A4 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CYP3A4
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CYP3A4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.