CYP3A4 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore CYP3A4 gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Introcelluar Protein.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, erythromycin, and chloroquine. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2020]

Target ID	GM-IP0038
Target Name	CYP3A4
Gene Group ldentifer （Target Gene ID in Homo species)	1576
Gene ID	1576 (Homo sapiens)
Target Alternative Names	1,4-cineole 2-exo-monooxygenase,8-cineole 2-exo-monooxygenase,Albendazole monooxygenase (sulfoxide-forming),Albendazole sulfoxidase,CP33,CP34,CYP3A,CYP3A3,CYP3A4,CYPIIIA3,CYPIIIA4,Cholesterol 25-hydroxylase,Cytochrome P450 3A3,Cytochrome P450 3A4,Cytochrome P450 HLp,Cytochrome P450 NF-25,Cytochrome P450-PCN1,HLP,NF-25,Nifedipine oxidase,P450C3,P450PCN1,Quinine 3-monooxygenase,VDDR3
Uniprot Accession	P08684
Protein Sub-location	Introcelluar Protein
Category	Therapeutics Target
Disease	cancer
Disease from KEGG	Metabolic pathways, Steroid hormone biosynthesis, Bile secretion, Chemical carcinogenesis - DNA adducts, Chemical carcinogenesis - receptor activation, Linoleic acid metabolism, Retinol metabolism, Drug metabolism - cytochrome P450
Gene Ensembl	ENSG00000160868
Target Classification	Tumor-associated antigen (TAA)

Pre-made viral vector of CYP3A4 cDNA Clones/ORF Plasmid

Cat No.	Product Name	NMID	GeneID	Species	Type	Marker	Fusion Tag	Promoter	Detail
pGMLV002275	Human CYP3A4/CP33/CP34 Lentivirus plasmid	NM_017460.6	1576	Human	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMAP000372	Human CYP3A4/CP33/CP34 Adenovirus plasmid	BC069418	1576	Human	Adenovirus plasmid	GFP	3xflag (C-Terminal)	EF1	Detail
pGMPC001504	Human CYP3A4/CP33/CP34 Mammalian (Non-Viral Vector) plasmid	NM_017460.6	1576	Human	Mammalian (Non-Viral Vector) plasmid	Null	6xHis (C-Terminal)	T7	Detail
vGMLV002275	Human CYP3A4/CP33/CP34 Lentivirus particle	NM_017460.6	1576	Human	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMAP000372	Human CYP3A4/CP33/CP34 Adenovirus particle	BC069418	1576	Human	Adenovirus particle	GFP	3xflag (C-Terminal)	EF1	Detail

CYP3A4 siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.	Product Name	GeneID	Species	Grade	Detail
pGMoligo1576	Pre-made Human CYP3A4/HLP/CP33 siRNA oligo Duplex	1576	Human	In-vitro grade; in-vivo grade	Detail

CYP3A4 antibody/GMab

Cat No.	Species	Antibody Name	Format	Classified by tag	Detail
GM-Tg-hg-IP0038-Ab	Human	Anti-Human CYP3A4 monoclonal antibody	mab	Therapeutics Target antibody	Detail

CYP3A4 recombinant protein

Cat No.	Species	Antigen Name	Expression Platform	Detail
GM-Tg-hg-IP0038-Ag	Human	Human CYP3A4 recombinant protein	Mammalian cell	Detail