Recombinant multi-species FKBP1A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FKBP1A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]
The Alternative Names of target: FKBP1A,Peptidyl-prolyl cis-trans isomerase FKBP1A,PPIase FKBP1A,12 kDa FK506-binding protein (12 kDa FKBP, FKBP-12), Calstabin-1, FK506-binding protein 1A (FKBP-1A), Immunophilin FKBP12, Rotamase,FKBP1,PKC12,PKCI2,FKBP12,PPIASE,FKBP-12,FKBP-1A

Target products collectionGo to FKBP1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0019-Ab-1/ GM-Tg-hg-IP0019-Ab-2 Human FKBP1A protein Human
GM-Tg-rg-IP0019-Ab-1/ GM-Tg-rg-IP0019-Ab-2 Rat FKBP1A protein Rat
GM-Tg-mg-IP0019-Ab-1/ GM-Tg-mg-IP0019-Ab-2 Mouse FKBP1A protein Mouse
GM-Tg-cynog-IP0019-Ab-1/ GM-Tg-cynog-IP0019-Ab-2 Cynomolgus/Rhesus macaque FKBP1A monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0019-Ab-1/ GM-Tg-felg-IP0019-Ab-2 Feline FKBP1A protein Feline
GM-Tg-cang-IP0019-Ab-1/ GM-Tg-cang-IP0019-Ab-2 Canine FKBP1A protein Canine
GM-Tg-bovg-IP0019-Ab-1/ GM-Tg-bovg-IP0019-Ab-2 Bovine FKBP1A protein Bovine
GM-Tg-equg-IP0019-Ab-1/ GM-Tg-equg-IP0019-Ab-2 Equine FKBP1A protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0019-Ab-1/ GM-Tg-hg-IP0019-Ab-2; GM-Tg-rg-IP0019-Ab-1/ GM-Tg-rg-IP0019-Ab-2;
GM-Tg-mg-IP0019-Ab-1/ GM-Tg-mg-IP0019-Ab-2; GM-Tg-cynog-IP0019-Ab-1/ GM-Tg-cynog-IP0019-Ab-2;
GM-Tg-felg-IP0019-Ab-1/ GM-Tg-felg-IP0019-Ab-2; GM-Tg-cang-IP0019-Ab-1/ GM-Tg-cang-IP0019-Ab-2;
GM-Tg-bovg-IP0019-Ab-1/ GM-Tg-bovg-IP0019-Ab-2; GM-Tg-equg-IP0019-Ab-1/ GM-Tg-equg-IP0019-Ab-2
Products Name FKBP1A protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name FKBP1A
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FKBP1A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.