Recombinant multi-species CYP2D6/7 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CYP2D6/7 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
The Alternative Names of target: 7,CPD6,CYP2D,CYP2D15,CYP2D6,CYP2D7AP,CYP2D7BP,CYP2D7P2,CYP2D8P2,CYP2DL1,CYPIID15,CYPIID6,Cholesterol 25-hydroxylase,Cytochrome P450 2D6,Cytochrome P450-DB1,Debrisoquine 4-hydroxylase,P450-DB1,P450C2D,P450DB1

Target products collectionGo to CYP2D6/7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0015-Ag-1/ GM-Tg-hg-IP0015-Ag-2 Human CYP2D6/7 protein Human
GM-Tg-rg-IP0015-Ag-1/ GM-Tg-rg-IP0015-Ag-2 Rat CYP2D6/7 protein Rat
GM-Tg-mg-IP0015-Ag-1/ GM-Tg-mg-IP0015-Ag-2 Mouse CYP2D6/7 protein Mouse
GM-Tg-cynog-IP0015-Ag-1/ GM-Tg-cynog-IP0015-Ag-2 Cynomolgus/Rhesus macaque CYP2D6/7 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0015-Ag-1/ GM-Tg-felg-IP0015-Ag-2 Feline CYP2D6/7 protein Feline
GM-Tg-cang-IP0015-Ag-1/ GM-Tg-cang-IP0015-Ag-2 Canine CYP2D6/7 protein Canine
GM-Tg-bovg-IP0015-Ag-1/ GM-Tg-bovg-IP0015-Ag-2 Bovine CYP2D6/7 protein Bovine
GM-Tg-equg-IP0015-Ag-1/ GM-Tg-equg-IP0015-Ag-2 Equine CYP2D6/7 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0015-Ag-1/ GM-Tg-hg-IP0015-Ag-2; GM-Tg-rg-IP0015-Ag-1/ GM-Tg-rg-IP0015-Ag-2;
GM-Tg-mg-IP0015-Ag-1/ GM-Tg-mg-IP0015-Ag-2; GM-Tg-cynog-IP0015-Ag-1/ GM-Tg-cynog-IP0015-Ag-2;
GM-Tg-felg-IP0015-Ag-1/ GM-Tg-felg-IP0015-Ag-2; GM-Tg-cang-IP0015-Ag-1/ GM-Tg-cang-IP0015-Ag-2;
GM-Tg-bovg-IP0015-Ag-1/ GM-Tg-bovg-IP0015-Ag-2; GM-Tg-equg-IP0015-Ag-1/ GM-Tg-equg-IP0015-Ag-2
Products Name CYP2D6/7 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CYP2D6/7
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CYP2D6/7 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.