Explore CYP2D6/7 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
| Target ID |
GM-IP0015
|
| Target Name |
CYP2D6/7
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1565
|
| Gene ID |
100500743 (Felis catus), 1565 (Homo sapiens), 415120 (Canis lupus familiaris)
|
| Target Alternative Names |
7,CPD6,CYP2D,CYP2D15,CYP2D6,CYP2D7AP,CYP2D7BP,CYP2D7P2,CYP2D8P2,CYP2DL1,CYPIID15,CYPIID6,Cholesterol 25-hydroxylase,Cytochrome P450 2D6,Cytochrome P450-DB1,Debrisoquine 4-hydroxylase,P450-DB1,P450C2D,P450DB1
|
| Uniprot Accession |
P10635,Q29473
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Endocrine resistance, Serotonergic synapse, Drug metabolism - cytochrome P450
|
| Gene Ensembl |
ENSG00000100197, ENSCAFG00845014943
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of CYP2D6/7 cDNA Clones/ORF Plasmid
CYP2D6/7 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1565 | Pre-made Human CYP2D6/CPD6/CYP2D siRNA oligo Duplex | 1565 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100500743 | Pre-made Cat/Feline CYP2D6 siRNA oligo Duplex | 100500743 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo415120 | Pre-made Dog/Canine CYP2D15/CYP2D/CYPIID15 siRNA oligo Duplex | 415120 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
CYP2D6/7 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0015-Ab | Human | Anti-Human CYP2D6/7 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0015-Ab | Cat/Feline | Anti-Cat/Feline CYP2D6/7 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0015-Ab | Dog/Canine | Anti-Dog/Canine CYP2D6/7 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
CYP2D6/7 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0015-Ag | Human | Human CYP2D6/7 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0015-Ag | Cat/Feline | Cat/Feline CYP2D6/7 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0015-Ag | Dog/Canine | Dog/Canine CYP2D6/7 recombinant protein | Mammalian cell | Detail |
