Recombinant multi-species PDE3A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PDE3A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
The Alternative Names of target: 5'-cyclic phosphodiesterase 3A,A930022O17Rik,CGI-PDE,CGI-PDE A,CGI-PDE-A,Cyclic GMP-inhibited phosphodiesterase A (CGI-PDE A),HTNB,PDE3A,Pde3a,RNPDE3A,cGMP-inhibited 3',cGMP-inhibited cAMP phosphodiesterase (cGI-PDE)

Target products collectionGo to PDE3A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0012-Ag-1/ GM-Tg-hg-IP0012-Ag-2 Human PDE3A protein Human
GM-Tg-rg-IP0012-Ag-1/ GM-Tg-rg-IP0012-Ag-2 Rat PDE3A protein Rat
GM-Tg-mg-IP0012-Ag-1/ GM-Tg-mg-IP0012-Ag-2 Mouse PDE3A protein Mouse
GM-Tg-cynog-IP0012-Ag-1/ GM-Tg-cynog-IP0012-Ag-2 Cynomolgus/Rhesus macaque PDE3A protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0012-Ag-1/ GM-Tg-felg-IP0012-Ag-2 Feline PDE3A protein Feline
GM-Tg-cang-IP0012-Ag-1/ GM-Tg-cang-IP0012-Ag-2 Canine PDE3A protein Canine
GM-Tg-bovg-IP0012-Ag-1/ GM-Tg-bovg-IP0012-Ag-2 Bovine PDE3A protein Bovine
GM-Tg-equg-IP0012-Ag-1/ GM-Tg-equg-IP0012-Ag-2 Equine PDE3A protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0012-Ag-1/ GM-Tg-hg-IP0012-Ag-2; GM-Tg-rg-IP0012-Ag-1/ GM-Tg-rg-IP0012-Ag-2;
GM-Tg-mg-IP0012-Ag-1/ GM-Tg-mg-IP0012-Ag-2; GM-Tg-cynog-IP0012-Ag-1/ GM-Tg-cynog-IP0012-Ag-2;
GM-Tg-felg-IP0012-Ag-1/ GM-Tg-felg-IP0012-Ag-2; GM-Tg-cang-IP0012-Ag-1/ GM-Tg-cang-IP0012-Ag-2;
GM-Tg-bovg-IP0012-Ag-1/ GM-Tg-bovg-IP0012-Ag-2; GM-Tg-equg-IP0012-Ag-1/ GM-Tg-equg-IP0012-Ag-2
Products Name PDE3A protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PDE3A
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PDE3A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.