Explore PDE3A gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
| Target ID |
GM-IP0012
|
| Target Name |
PDE3A
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5139
|
| Gene ID |
100034086 (Equus caballus), 101088586 (Felis catus), 50678 (Rattus norvegicus), 5139 (Homo sapiens)
536636 (Bos taurus), 54611 (Mus musculus), 610836 (Canis lupus familiaris), 704524 (Macaca mulatta)
|
| Target Alternative Names |
5'-cyclic phosphodiesterase 3A,A930022O17Rik,CGI-PDE,CGI-PDE A,CGI-PDE-A,Cyclic GMP-inhibited phosphodiesterase A (CGI-PDE A),HTNB,PDE3A,Pde3a,RNPDE3A,cGMP-inhibited 3',cGMP-inhibited cAMP phosphodiesterase (cGI-PDE)
|
| Uniprot Accession |
Q62865,Q14432,Q9Z0X4
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Renin secretion, Morphine addiction
|
| Gene Ensembl |
ENSECAG00000016360, ENSG00000172572, ENSBTAG00000017260, ENSMUSG00000041741, ENSCAFG00845015831, ENSMMUG00000008269
|
PDE3A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5139 | Pre-made Human PDE3A/HTNB/CGI-PDE siRNA oligo Duplex | 5139 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo50678 | Pre-made Rat Pde3a/RNPDE3A siRNA oligo Duplex | 50678 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo54611 | Pre-made Mouse Pde3a/A930022O17Rik siRNA oligo Duplex | 54611 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo704524 | Pre-made Cynomolgus/Rhesus macaque PDE3A siRNA oligo Duplex | 704524 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101088586 | Pre-made Cat/Feline PDE3A siRNA oligo Duplex | 101088586 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo610836 | Pre-made Dog/Canine PDE3A siRNA oligo Duplex | 610836 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo536636 | Pre-made Bovines/Cattle PDE3A siRNA oligo Duplex | 536636 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034086 | Pre-made Equine/Horse PDE3A siRNA oligo Duplex | 100034086 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PDE3A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0012-Ab | Human | Anti-Human PDE3A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0012-Ab | Rat | Anti-Rat PDE3A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0012-Ab | Mouse | Anti-Mouse PDE3A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0012-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PDE3A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0012-Ab | Cat/Feline | Anti-Cat/Feline PDE3A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0012-Ab | Dog/Canine | Anti-Dog/Canine PDE3A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0012-Ab | Bovines/Cattle | Anti-Bovines/Cattle PDE3A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0012-Ab | Equine/Horse | Anti-Equine/Horse PDE3A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PDE3A recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0012-Ag | Human | Human PDE3A recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0012-Ag | Rat | Rat PDE3A recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0012-Ag | Mouse | Mouse PDE3A recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0012-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PDE3A recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0012-Ag | Cat/Feline | Cat/Feline PDE3A recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0012-Ag | Dog/Canine | Dog/Canine PDE3A recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0012-Ag | Bovines/Cattle | Bovines/Cattle PDE3A recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0012-Ag | Equine/Horse | Equine/Horse PDE3A recombinant protein | Mammalian cell | Detail |
