Recombinant multi-species TIM3/HAVCR2/CD366 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TIM3/HAVCR2/CD366 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
The Alternative Names of target: CD366,HAVCR2,HAVcr-2,Havcr2,Hepatitis A virus cellular receptor 2,KIM-3,SPTCL,T-cell immunoglobulin and mucin domain-containing protein 3 (TIMD-3),T-cell immunoglobulin mucin receptor 3 (TIM-3),T-cell membrane protein 3,TIM-3,TIM3,TIMD-3,TIMD3,Tim-3,Tim3,Timd3,tim3

Target products collectionGo to TIM3/HAVCR2/CD366 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0004-Ag-1/ GM-Tg-hg-IP0004-Ag-2 Human TIM3/HAVCR2/CD366 protein Human
GM-Tg-rg-IP0004-Ag-1/ GM-Tg-rg-IP0004-Ag-2 Rat TIM3/HAVCR2/CD366 protein Rat
GM-Tg-mg-IP0004-Ag-1/ GM-Tg-mg-IP0004-Ag-2 Mouse TIM3/HAVCR2/CD366 protein Mouse
GM-Tg-cynog-IP0004-Ag-1/ GM-Tg-cynog-IP0004-Ag-2 Cynomolgus/Rhesus macaque TIM3/HAVCR2/CD366 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0004-Ag-1/ GM-Tg-felg-IP0004-Ag-2 Feline TIM3/HAVCR2/CD366 protein Feline
GM-Tg-cang-IP0004-Ag-1/ GM-Tg-cang-IP0004-Ag-2 Canine TIM3/HAVCR2/CD366 protein Canine
GM-Tg-bovg-IP0004-Ag-1/ GM-Tg-bovg-IP0004-Ag-2 Bovine TIM3/HAVCR2/CD366 protein Bovine
GM-Tg-equg-IP0004-Ag-1/ GM-Tg-equg-IP0004-Ag-2 Equine TIM3/HAVCR2/CD366 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0004-Ag-1/ GM-Tg-hg-IP0004-Ag-2; GM-Tg-rg-IP0004-Ag-1/ GM-Tg-rg-IP0004-Ag-2;
GM-Tg-mg-IP0004-Ag-1/ GM-Tg-mg-IP0004-Ag-2; GM-Tg-cynog-IP0004-Ag-1/ GM-Tg-cynog-IP0004-Ag-2;
GM-Tg-felg-IP0004-Ag-1/ GM-Tg-felg-IP0004-Ag-2; GM-Tg-cang-IP0004-Ag-1/ GM-Tg-cang-IP0004-Ag-2;
GM-Tg-bovg-IP0004-Ag-1/ GM-Tg-bovg-IP0004-Ag-2; GM-Tg-equg-IP0004-Ag-1/ GM-Tg-equg-IP0004-Ag-2
Products Name TIM3/HAVCR2/CD366 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name TIM3/HAVCR2/CD366
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TIM3/HAVCR2/CD366 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.