Explore TIM3/HAVCR2/CD366 gene products and cross-species
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
| Target ID |
GM-IP0004
|
| Target Name |
TIM3/HAVCR2/CD366
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
84868
|
| Gene ID |
100071246 (Equus caballus), 101089981 (Felis catus), 171285 (Mus musculus), 363578 (Rattus norvegicus)
479318 (Canis lupus familiaris), 714891 (Macaca mulatta), 768047 (Bos taurus), 84868 (Homo sapiens)
|
| Target Alternative Names |
CD366,HAVCR2,HAVcr-2,Havcr2,Hepatitis A virus cellular receptor 2,KIM-3,SPTCL,T-cell immunoglobulin and mucin domain-containing protein 3 (TIMD-3),T-cell immunoglobulin mucin receptor 3 (TIM-3),T-cell membrane protein 3,TIM-3,TIM3,TIMD-3,TIMD3,Tim-3,Tim3,Timd3,tim3
|
| Uniprot Accession |
Q8VIM0,P0C0K5,Q8TDQ0
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000015318, ENSMUSG00000020399, ENSCAFG00845002443, ENSMMUG00000048691, ENSBTAG00000000495, ENSG00000135077
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of TIM3/HAVCR2/CD366 cDNA Clones/ORF Plasmid
TIM3/HAVCR2/CD366 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo84868 | Pre-made Human HAVCR2/TIM3/CD366 siRNA oligo Duplex | 84868 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo363578 | Pre-made Rat Havcr2/tim3 siRNA oligo Duplex | 363578 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo171285 | Pre-made Mouse Havcr2/Tim3/TIM-3 siRNA oligo Duplex | 171285 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714891 | Pre-made Cynomolgus/Rhesus macaque HAVCR2/Tim-3 siRNA oligo Duplex | 714891 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101089981 | Pre-made Cat/Feline HAVCR2 siRNA oligo Duplex | 101089981 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo479318 | Pre-made Dog/Canine HAVCR2 siRNA oligo Duplex | 479318 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo768047 | Pre-made Bovines/Cattle HAVCR2/Tim-3 siRNA oligo Duplex | 768047 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100071246 | Pre-made Equine/Horse HAVCR2 siRNA oligo Duplex | 100071246 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TIM3/HAVCR2/CD366 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0004-Ab | Human | Anti-Human TIM3/HAVCR2/CD366 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0004-Ab | Rat | Anti-Rat TIM3/HAVCR2/CD366 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0004-Ab | Mouse | Anti-Mouse TIM3/HAVCR2/CD366 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0004-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TIM3/HAVCR2/CD366 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0004-Ab | Cat/Feline | Anti-Cat/Feline TIM3/HAVCR2/CD366 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0004-Ab | Dog/Canine | Anti-Dog/Canine TIM3/HAVCR2/CD366 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0004-Ab | Bovines/Cattle | Anti-Bovines/Cattle TIM3/HAVCR2/CD366 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0004-Ab | Equine/Horse | Anti-Equine/Horse TIM3/HAVCR2/CD366 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
TIM3/HAVCR2/CD366 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0004-Ag | Human | Human TIM3/HAVCR2/CD366 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0004-Ag | Rat | Rat TIM3/HAVCR2/CD366 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0004-Ag | Mouse | Mouse TIM3/HAVCR2/CD366 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0004-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TIM3/HAVCR2/CD366 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0004-Ag | Cat/Feline | Cat/Feline TIM3/HAVCR2/CD366 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0004-Ag | Dog/Canine | Dog/Canine TIM3/HAVCR2/CD366 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0004-Ag | Bovines/Cattle | Bovines/Cattle TIM3/HAVCR2/CD366 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0004-Ag | Equine/Horse | Equine/Horse TIM3/HAVCR2/CD366 recombinant protein | Mammalian cell | Detail |
