Explore AMPK Gamma 1/PRKAG1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
| Target ID |
GM-TA151
|
| Target Name |
AMPK Gamma 1/PRKAG1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5571
|
| Gene ID |
100034096 (Equus caballus), 101094684 (Felis catus), 19082 (Mus musculus), 25520 (Rattus norvegicus) 282324 (Bos taurus), 486559 (Canis lupus familiaris), 5571 (Homo sapiens), 709298 (Macaca mulatta)
|
| Target Alternative Names |
5'-AMP-activated protein kinase subunit gamma-1,AMPK Gamma 1,AMPK gamma1,AMPK subunit gamma-1,AMPKG,AMPKg,PRKAG1,Prkaac,Prkag1,Prkga1
|
| Uniprot Accession |
O54950,P80385,P58108,P54619
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
FoxO signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Tight junction, Adipocytokine signaling pathway, Oxytocin signaling pathway, Insulin resistance, Alcoholic liver disease, Hypertrophic cardiomyopathy
|
| Gene Ensembl |
ENSECAG00000011134, ENSMUSG00000067713, ENSBTAG00000014426, ENSCAFG00845022388, ENSG00000181929, ENSMMUG00000015713
|
Pre-made viral vector of AMPK Gamma 1/PRKAG1 cDNA Clones/ORF Plasmid
AMPK Gamma 1/PRKAG1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5571 | Pre-made Human PRKAG1/AMPKG siRNA oligo Duplex | 5571 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25520 | Pre-made Rat Prkag1/Prkaac/Prkga1 siRNA oligo Duplex | 25520 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19082 | Pre-made Mouse Prkag1/Prkaac siRNA oligo Duplex | 19082 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo709298 | Pre-made Cynomolgus/Rhesus macaque PRKAG1 siRNA oligo Duplex | 709298 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101094684 | Pre-made Cat/Feline PRKAG1 siRNA oligo Duplex | 101094684 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486559 | Pre-made Dog/Canine PRKAG1 siRNA oligo Duplex | 486559 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282324 | Pre-made Bovines/Cattle PRKAG1 siRNA oligo Duplex | 282324 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034096 | Pre-made Equine/Horse PRKAG1 siRNA oligo Duplex | 100034096 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
AMPK Gamma 1/PRKAG1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-TA151-Ab | Human | Anti-Human AMPK Gamma 1/PRKAG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-TA151-Ab | Rat | Anti-Rat AMPK Gamma 1/PRKAG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-TA151-Ab | Mouse | Anti-Mouse AMPK Gamma 1/PRKAG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-TA151-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque AMPK Gamma 1/PRKAG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-TA151-Ab | Cat/Feline | Anti-Cat/Feline AMPK Gamma 1/PRKAG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-TA151-Ab | Dog/Canine | Anti-Dog/Canine AMPK Gamma 1/PRKAG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-TA151-Ab | Bovines/Cattle | Anti-Bovines/Cattle AMPK Gamma 1/PRKAG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-TA151-Ab | Equine/Horse | Anti-Equine/Horse AMPK Gamma 1/PRKAG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
AMPK Gamma 1/PRKAG1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-TA151-Ag | Human | Human AMPK Gamma 1/PRKAG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-TA151-Ag | Rat | Rat AMPK Gamma 1/PRKAG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-TA151-Ag | Mouse | Mouse AMPK Gamma 1/PRKAG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-TA151-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque AMPK Gamma 1/PRKAG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-TA151-Ag | Cat/Feline | Cat/Feline AMPK Gamma 1/PRKAG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-TA151-Ag | Dog/Canine | Dog/Canine AMPK Gamma 1/PRKAG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-TA151-Ag | Bovines/Cattle | Bovines/Cattle AMPK Gamma 1/PRKAG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-TA151-Ag | Equine/Horse | Equine/Horse AMPK Gamma 1/PRKAG1 recombinant protein | Mammalian cell | Detail |