Explore PLCG2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]
| Target ID |
GM-TA116
|
| Target Name |
PLCG2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5336
|
| Gene ID |
100055670 (Equus caballus), 100337091 (Bos taurus), 101080675 (Felis catus), 234779 (Mus musculus)
29337 (Rattus norvegicus), 489692 (Canis lupus familiaris), 5336 (Homo sapiens), 714173 (Macaca mulatta)
|
| Target Alternative Names |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2,APLAID,FCAS3,PLC-IV,PLC-gamma-2,PLCG2,PLCgamma2,Phosphoinositide phospholipase C-gamma-2,Phospholipase C-IV (PLC-IV),Phospholipase C-gamma-2 (PLC-gamma-2),Plcg-2,Plcg2
|
| Uniprot Accession |
Q8CIH5,P24135,P16885
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways, EGFR tyrosine kinase inhibitor resistance, ErbB signaling pathway, Ras signaling pathway, Calcium signaling pathway, Chemokine signaling pathway, NF-kappa B signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, Axon guidance, Osteoclast differentiation, Platelet activation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels, Thyroid hormone signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Growth hormone synthesis, secretion and action, Epithelial cell signaling in Helicobacter pylori infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Pathways in cancer, Proteoglycans in cancer, Glioma, Non-small cell lung cancer, Hepatocellular carcinoma
|
| Gene Ensembl |
ENSECAG00000000291, ENSBTAG00000002103, ENSMUSG00000034330, ENSCAFG00845017949, ENSG00000197943, ENSMMUG00000005334
|
PLCG2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5336 | Pre-made Human PLCG2/FCAS3/APLAID siRNA oligo Duplex | 5336 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29337 | Pre-made Rat Plcg2 siRNA oligo Duplex | 29337 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo234779 | Pre-made Mouse Plcg2/Plcg-2/PLCgamma2 siRNA oligo Duplex | 234779 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714173 | Pre-made Cynomolgus/Rhesus macaque PLCG2 siRNA oligo Duplex | 714173 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101080675 | Pre-made Cat/Feline PLCG2 siRNA oligo Duplex | 101080675 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489692 | Pre-made Dog/Canine PLCG2 siRNA oligo Duplex | 489692 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100337091 | Pre-made Bovines/Cattle PLCG2 siRNA oligo Duplex | 100337091 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100055670 | Pre-made Equine/Horse PLCG2 siRNA oligo Duplex | 100055670 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PLCG2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-TA116-Ab | Human | Anti-Human PLCG2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-TA116-Ab | Rat | Anti-Rat PLCG2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-TA116-Ab | Mouse | Anti-Mouse PLCG2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-TA116-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PLCG2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-TA116-Ab | Cat/Feline | Anti-Cat/Feline PLCG2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-TA116-Ab | Dog/Canine | Anti-Dog/Canine PLCG2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-TA116-Ab | Bovines/Cattle | Anti-Bovines/Cattle PLCG2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-TA116-Ab | Equine/Horse | Anti-Equine/Horse PLCG2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PLCG2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-TA116-Ag | Human | Human PLCG2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-TA116-Ag | Rat | Rat PLCG2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-TA116-Ag | Mouse | Mouse PLCG2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-TA116-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PLCG2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-TA116-Ag | Cat/Feline | Cat/Feline PLCG2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-TA116-Ag | Dog/Canine | Dog/Canine PLCG2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-TA116-Ag | Bovines/Cattle | Bovines/Cattle PLCG2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-TA116-Ag | Equine/Horse | Equine/Horse PLCG2 recombinant protein | Mammalian cell | Detail |
