Explore AMPK Beta 1/PRKAB1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]
| Target ID |
GM-TA082
|
| Target Name |
AMPK Beta 1/PRKAB1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5564
|
| Gene ID |
100034094 (Equus caballus), 101094051 (Felis catus), 19079 (Mus musculus), 486295 (Canis lupus familiaris) 534107 (Bos taurus), 5564 (Homo sapiens), 695737 (Macaca mulatta), 83803 (Rattus norvegicus)
|
| Target Alternative Names |
1300015D22Rik,5'-AMP-activated protein kinase subunit beta-1,AMPK,AMPK Beta 1,AMPK subunit beta-1,AMPKb,E430008F22,HAMPKb,PRKAB1,Prkab1
|
| Uniprot Accession |
Q9R078,Q5BIS9,Q9Y478,P80386
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
FoxO signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Tight junction, Adipocytokine signaling pathway, Oxytocin signaling pathway, Insulin resistance, Alcoholic liver disease, Hypertrophic cardiomyopathy
|
| Gene Ensembl |
ENSECAG00000011947, ENSMUSG00000029513, ENSCAFG00845028956, ENSBTAG00000005940, ENSG00000111725, ENSMMUG00000019860
|
Pre-made viral vector of AMPK Beta 1/PRKAB1 cDNA Clones/ORF Plasmid
AMPK Beta 1/PRKAB1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5564 | Pre-made Human PRKAB1/AMPK/HAMPKb siRNA oligo Duplex | 5564 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo83803 | Pre-made Rat Prkab1 siRNA oligo Duplex | 83803 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19079 | Pre-made Mouse Prkab1/E430008F22/1300015D22Rik siRNA oligo Duplex | 19079 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo695737 | Pre-made Cynomolgus/Rhesus macaque PRKAB1 siRNA oligo Duplex | 695737 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101094051 | Pre-made Cat/Feline PRKAB1 siRNA oligo Duplex | 101094051 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486295 | Pre-made Dog/Canine PRKAB1 siRNA oligo Duplex | 486295 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo534107 | Pre-made Bovines/Cattle PRKAB1 siRNA oligo Duplex | 534107 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034094 | Pre-made Equine/Horse PRKAB1 siRNA oligo Duplex | 100034094 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
AMPK Beta 1/PRKAB1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-TA082-Ab | Human | Anti-Human AMPK Beta 1/PRKAB1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-TA082-Ab | Rat | Anti-Rat AMPK Beta 1/PRKAB1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-TA082-Ab | Mouse | Anti-Mouse AMPK Beta 1/PRKAB1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-TA082-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque AMPK Beta 1/PRKAB1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-TA082-Ab | Cat/Feline | Anti-Cat/Feline AMPK Beta 1/PRKAB1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-TA082-Ab | Dog/Canine | Anti-Dog/Canine AMPK Beta 1/PRKAB1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-TA082-Ab | Bovines/Cattle | Anti-Bovines/Cattle AMPK Beta 1/PRKAB1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-TA082-Ab | Equine/Horse | Anti-Equine/Horse AMPK Beta 1/PRKAB1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
AMPK Beta 1/PRKAB1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-TA082-Ag | Human | Human AMPK Beta 1/PRKAB1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-TA082-Ag | Rat | Rat AMPK Beta 1/PRKAB1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-TA082-Ag | Mouse | Mouse AMPK Beta 1/PRKAB1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-TA082-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque AMPK Beta 1/PRKAB1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-TA082-Ag | Cat/Feline | Cat/Feline AMPK Beta 1/PRKAB1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-TA082-Ag | Dog/Canine | Dog/Canine AMPK Beta 1/PRKAB1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-TA082-Ag | Bovines/Cattle | Bovines/Cattle AMPK Beta 1/PRKAB1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-TA082-Ag | Equine/Horse | Equine/Horse AMPK Beta 1/PRKAB1 recombinant protein | Mammalian cell | Detail |