Explore Arginase-1/ARG1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
| Target ID |
GM-TA042
|
| Target Name |
Arginase-1/ARG1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
383
|
| Gene ID |
100073086 (Equus caballus), 101089865 (Felis catus), 11846 (Mus musculus), 29221 (Rattus norvegicus)
383 (Homo sapiens), 474823 (Canis lupus familiaris), 513608 (Bos taurus), 710410 (Macaca mulatta)
|
| Target Alternative Names |
AI,ARG1,Arg-1,Arg1,Arginase-1,Liver-type arginase,PGIF,Type I arginase
|
| Uniprot Accession |
Q61176,P07824,P05089,Q2KJ64
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease from KEGG |
Metabolic pathways, Amoebiasis
|
| Gene Ensembl |
ENSECAG00000023485, ENSMUSG00000019987, ENSG00000118520, ENSCAFG00845006568, ENSBTAG00000012403, ENSMMUG00000017540
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of Arginase-1/ARG1 cDNA Clones/ORF Plasmid
Arginase-1/ARG1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo383 | Pre-made Human ARG1 siRNA oligo Duplex | 383 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29221 | Pre-made Rat Arg1 siRNA oligo Duplex | 29221 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11846 | Pre-made Mouse Arg1/AI/PGIF siRNA oligo Duplex | 11846 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710410 | Pre-made Cynomolgus/Rhesus macaque ARG1 siRNA oligo Duplex | 710410 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101089865 | Pre-made Cat/Feline ARG1 siRNA oligo Duplex | 101089865 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo474823 | Pre-made Dog/Canine ARG1 siRNA oligo Duplex | 474823 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo513608 | Pre-made Bovines/Cattle ARG1 siRNA oligo Duplex | 513608 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100073086 | Pre-made Equine/Horse ARG1 siRNA oligo Duplex | 100073086 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Arginase-1/ARG1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-TA042-Ab | Human | Anti-Human Arginase-1/ARG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-TA042-Ab | Rat | Anti-Rat Arginase-1/ARG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-TA042-Ab | Mouse | Anti-Mouse Arginase-1/ARG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-TA042-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Arginase-1/ARG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-TA042-Ab | Cat/Feline | Anti-Cat/Feline Arginase-1/ARG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-TA042-Ab | Dog/Canine | Anti-Dog/Canine Arginase-1/ARG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-TA042-Ab | Bovines/Cattle | Anti-Bovines/Cattle Arginase-1/ARG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-TA042-Ab | Equine/Horse | Anti-Equine/Horse Arginase-1/ARG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
Arginase-1/ARG1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-TA042-Ag | Human | Human Arginase-1/ARG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-TA042-Ag | Rat | Rat Arginase-1/ARG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-TA042-Ag | Mouse | Mouse Arginase-1/ARG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-TA042-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Arginase-1/ARG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-TA042-Ag | Cat/Feline | Cat/Feline Arginase-1/ARG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-TA042-Ag | Dog/Canine | Dog/Canine Arginase-1/ARG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-TA042-Ag | Bovines/Cattle | Bovines/Cattle Arginase-1/ARG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-TA042-Ag | Equine/Horse | Equine/Horse Arginase-1/ARG1 recombinant protein | Mammalian cell | Detail |
