Explore CD8/CD8A/CD8a gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]
| Target ID |
GM-TA040
|
| Target Name |
CD8/CD8A/CD8a
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
925
|
| Gene ID |
100066774 (Equus caballus), 12525 (Mus musculus), 24930 (Rattus norvegicus), 281060 (Bos taurus) 403157 (Canis lupus familiaris), 493799 (Felis catus), 698329 (Macaca mulatta), 925 (Homo sapiens)
|
| Target Alternative Names |
CD8,CD8A,CD8a,CD8alpha,Cd8a,IMD116,Leu2,Ly-2,Ly-35,Ly-B,Lyt-2,T-cell surface glycoprotein CD8 alpha chain,T-lymphocyte differentiation antigen T8/Leu-2,p32
|
| Uniprot Accession |
P01731,P07725,P31783,P33706,P41688,P01732
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease from KEGG |
Cell adhesion molecules, Antigen processing and presentation, Hematopoietic cell lineage, T cell receptor signaling pathway, Yersinia infection
|
| Gene Ensembl |
ENSECAG00000013261, ENSMUSG00000053977, ENSBTAG00000021141, ENSCAFG00845013158, ENSMMUG00000003524, ENSG00000153563
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of CD8/CD8A/CD8a cDNA Clones/ORF Plasmid
CD8/CD8A/CD8a siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo925 | Pre-made Human CD8A/CD8/p32 siRNA oligo Duplex | 925 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24930 | Pre-made Rat Cd8a siRNA oligo Duplex | 24930 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12525 | Pre-made Mouse Cd8a/Ly-2/Ly-B siRNA oligo Duplex | 12525 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo698329 | Pre-made Cynomolgus/Rhesus macaque CD8A siRNA oligo Duplex | 698329 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493799 | Pre-made Cat/Feline CD8A siRNA oligo Duplex | 493799 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403157 | Pre-made Dog/Canine CD8A siRNA oligo Duplex | 403157 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281060 | Pre-made Bovines/Cattle CD8A siRNA oligo Duplex | 281060 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100066774 | Pre-made Equine/Horse CD8A siRNA oligo Duplex | 100066774 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CD8/CD8A/CD8a antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-TA040-Ab | Human | Anti-Human CD8/CD8A/CD8a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-TA040-Ab | Rat | Anti-Rat CD8/CD8A/CD8a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-TA040-Ab | Mouse | Anti-Mouse CD8/CD8A/CD8a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-TA040-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CD8/CD8A/CD8a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-TA040-Ab | Cat/Feline | Anti-Cat/Feline CD8/CD8A/CD8a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-TA040-Ab | Dog/Canine | Anti-Dog/Canine CD8/CD8A/CD8a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-TA040-Ab | Bovines/Cattle | Anti-Bovines/Cattle CD8/CD8A/CD8a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-TA040-Ab | Equine/Horse | Anti-Equine/Horse CD8/CD8A/CD8a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CD8/CD8A/CD8a VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-TA040-Ag | Human | Human CD8/CD8A/CD8a VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-TA040-Ag | Rat | Rat CD8/CD8A/CD8a VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-TA040-Ag | Mouse | Mouse CD8/CD8A/CD8a VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-TA040-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CD8/CD8A/CD8a VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-TA040-Ag | Cat/Feline | Cat/Feline CD8/CD8A/CD8a VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-TA040-Ag | Dog/Canine | Dog/Canine CD8/CD8A/CD8a VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-TA040-Ag | Bovines/Cattle | Bovines/Cattle CD8/CD8A/CD8a VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-TA040-Ag | Equine/Horse | Equine/Horse CD8/CD8A/CD8a VLP (virus-like particle) | HEK293 | Products Developing |